Overview

  • Product name
    Xestospongin C
  • Description
    Potent, selective, reversible IP3 receptor antagonist
  • Alternative names
    • Araguspongine E
    • XeC
  • Biological description
    Potent, selective, reversible IP3 receptor antagonist (IC50 = 350 nM). Inhibits IP3-mediated Ca2+ release from ER and SR. 30-Fold selectivity over ryanodine receptor. Inhibits voltage-dependent Ca2+ and K+ channels at higher concentrations. Cell-permeable.
  • Purity
    > 90%

Properties

References

This product has been referenced in:
  • Zhao Y  et al. Anesthetic-induced neurodegeneration mediated via inositol 1,4,5-trisphosphate receptors. J Pharmacol Exp Ther 333:14-22 (2010). Read more (PubMed: 20086058) »
  • Oka T  et al. Xestospongin C, a novel blocker of IP3 receptor, attenuates the increase in cytosolic calcium level and degranulation that is induced by antigen in RBL-2H3 mast cells. Br J Pharmacol 135:1959-66 (2002). Read more (PubMed: 11959799) »
  • Ozaki H  et al. Inhibitory mechanism of xestospongin-C on contraction and ion channels in the intestinal smooth muscle. Br J Pharmacol 137:1207-12 (2002). Read more (PubMed: 12466229) »

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Customer reviews and Q&As

We have some inventory of Xestospongin C in clear glass. We are currently in the process of changing from clear glass vials to amber vials for this product. Supplying Xestospongin C in amber vials is a precautionary measure as it appears that Xestospon...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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