• Product nameAnti-XPA antibody
    See all XPA primary antibodies
  • Description
    Rabbit polyclonal to XPA
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rhesus monkey, Gorilla, Elephant
  • Immunogen

    Synthetic peptide, corresponding to a region between residue 1 and 50 of human XPA (NP_000371.1).

  • Positive control
    • Human controls: Breast Carcinoma, Colon Carcinoma, Ovarian Carcinoma, Prostate Carcinoma, Stomach Adenocarcinoma, Testicular Seminoma Mouse controls: Teratoma


  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesab84780 was affinity purified using an epitope specific to XPA immobilized on solid support.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas


Our Abpromise guarantee covers the use of ab84780 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesIHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

    Likely to work with frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionInvolved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.
    • Tissue specificityExpressed in various cell lines and in skin fibroblasts.
    • Involvement in diseaseDefects in XPA are a cause of xeroderma pigmentosum complementation group A (XP-A) [MIM:278700]; also known as xeroderma pigmentosum type 1 (XP1). XP-A is a rare human autosomal recessive disease characterized by solar sensitivity, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. Group A patients show the most severe skin symptoms and progressive neurological disorders.
    • Sequence similaritiesBelongs to the XPA family.
    • Post-translational
      Phosphorylated upon DNA damage, probably by ATM or ATR.
      Ubiquitinated by HERC2 leading to degradation by the proteasome.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • DNA repair protein complementing XP A cells antibody
      • DNA repair protein complementing XP-A cells antibody
      • DNA repair protein complementing XPA cells antibody
      • Excision repair controlling antibody
      • Xeroderma pigmentosum 1 antibody
      • Xeroderma pigmentosum complementation group A antibody
      • Xeroderma pigmentosum group A complementing protein antibody
      • Xeroderma pigmentosum group A-complementing protein antibody
      • XP 1 antibody
      • XP1 antibody
      • xpa antibody
      • XPA_HUMAN antibody
      • Xpac antibody
      see all

    Anti-XPA antibody images

    • ab84780, at a 1/500 dilution, staining XPA in formalin fixed, paraffin embedded human ovarian tumor by Immunohistochemistry using DAB staining.
    • ab84780, at a 1/500 dilution, staining XPA in formalin fixed, paraffin embedded human colon carcinoma by Immunohistochemistry using DAB staining.
    • ab84780, at a 1/100 dilution, staining XPA in formalin fixed, paraffin embedded mouse teratoma by Immunohistochemistry using DAB staining.

    References for Anti-XPA antibody (ab84780)

    ab84780 has not yet been referenced specifically in any publications.

    Product Wall

    Abcam guarantees this product to work in the species/application used in this Abreview.
    Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample Mouse Tissue sections (Adult skin)
    Specification Adult skin
    Fixative Paraformaldehyde
    Antigen retrieval step Heat mediated - Buffer/Enzyme Used: Ciitric buffer, pH 6
    Permeabilization No
    Blocking step Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 10% · Temperature: 20°C

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    Submitted Mar 24 2010