Overview

  • Product name
  • Description
    Rabbit polyclonal to XPA
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    KLH conjugated synthetic peptide selected from the C-terminal region of Human XPA (NP_000371.1)

  • Positive control
    • NCI-H460 cell lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage buffer
    Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    This antibody is purified through a protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab93400 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notes
    ELISA: 1/1000.
    WB: 1/100 - 1/500. Predicted molecular weight: 31 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.
    • Tissue specificity
      Expressed in various cell lines and in skin fibroblasts.
    • Involvement in disease
      Defects in XPA are a cause of xeroderma pigmentosum complementation group A (XP-A) [MIM:278700]; also known as xeroderma pigmentosum type 1 (XP1). XP-A is a rare human autosomal recessive disease characterized by solar sensitivity, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. Group A patients show the most severe skin symptoms and progressive neurological disorders.
    • Sequence similarities
      Belongs to the XPA family.
    • Post-translational
      modifications
      Phosphorylated upon DNA damage, probably by ATM or ATR.
      Ubiquitinated by HERC2 leading to degradation by the proteasome.
    • Cellular localization
      Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • DNA repair protein complementing XP A cells antibody
      • DNA repair protein complementing XP-A cells antibody
      • DNA repair protein complementing XPA cells antibody
      • Excision repair controlling antibody
      • Xeroderma pigmentosum 1 antibody
      • Xeroderma pigmentosum complementation group A antibody
      • Xeroderma pigmentosum group A complementing protein antibody
      • Xeroderma pigmentosum group A-complementing protein antibody
      • XP 1 antibody
      • XP1 antibody
      • xpa antibody
      • XPA_HUMAN antibody
      • Xpac antibody
      see all

    Images

    • Anti-XPA antibody (ab93400) at 1/100 dilution + NCI-H460 cell line lysates at 35 µg

      Predicted band size : 31 kDa

    References

    ab93400 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab93400.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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