Use at an assay dependent concentration. PubMed: 24726326
FunctionStructure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link.
Involvement in diseaseDefects in ERCC4 are the cause of xeroderma pigmentosum complementation group F (XP-F) [MIM:278760]; also known as xeroderma pigmentosum VI (XP6). XP-F is an autosomal recessive disease characterized by hypersensitivity of the skin to sunlight followed by high incidence of skin cancer and frequent neurologic abnormalities. Defects in ERCC4 are a cause of XFE progeroid syndrome (XFEPS) [MIM:610965]. This syndrome is illustrated by one patient who presented with dwarfism, cachexia and microcephaly.
Sequence similaritiesBelongs to the XPF family. Contains 1 ERCC4 domain.
excision repair cross-complementation group 4 antibody
RAD 1 antibody
Xeroderma pigmentosum complementation group F antibody
Xeroderma pigmentosum group F complementing protein antibody
Xeroderma pigmentosum group F-complementing protein antibody
Xeroderma pigmentosum VI antibody
XP, group G antibody
Anti-XPF antibody images
Western blot - XPF antibody (ab73720)
All lanes : Anti-XPF antibody (ab73720) at 1/500 dilution
Lane 1 : Extracts from 293 cells Lane 2 : Extracts from 293 cells with immunizing peptide at 5 µg
Lysates/proteins at 15 µg per lane.
Predicted band size : 103 kDa Observed band size : 103 kDa
References for Anti-XPF antibody (ab73720)
This product has been referenced in:
Hodskinson MR et al. Mouse SLX4 is a tumor suppressor that stimulates the activity of the nuclease XPF-ERCC1 in DNA crosslink repair. Mol Cell54:472-84 (2014).
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