FunctionA metalloprotease that may play a role in the inflammatory process and other reactions produced in response to injury or infection. May also play a role in the metabolism of the vasodilator bradykinin.
Tissue specificityExpressed in kidney, lung, heart, placenta, liver, small intestine and colon. No expression in brain, skeletal muscle, pancreas, spleen, thymus, prostate, testis and ovary.
Involvement in diseaseAngioedema induced by ACE inhibitors
Sequence similaritiesBelongs to the peptidase M24B family.