Overview

  • Product name
  • Description
    Rabbit polyclonal to XPNPEP3
  • Tested applications
    Suitable for: IHC-P, ICC/IF, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Cow
  • Immunogen

    Recombinant fragment within Human XPNPEP3 aa 12-507. The exact sequence is proprietary. NP_071381.1
    Database link: Q9NQH7

  • Positive control
    • Human kidney tissue; A549 cells; A431 whole cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab192826 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 7.5 µg/ml.
ICC/IF 1/100 - 1/1000.
WB 1/500 - 1/3000. Predicted molecular weight: 57 kDa.

Target

  • Tissue specificity
    Isoform 1 and isoform 2 are widely expressed, with isoform 1 being more abundant.
  • Involvement in disease
    Defects in XPNPEP3 are the cause of nephronophthisis-like nephropathy type 1 (NPHPL1) [MIM:613159]. A disorder with features of nephronophthisis, a cystic kidney disease leading to end-stage renal failure. Nephronophthisis is histologically characterized by modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts. Typical clinical manifestation are chronic renal failure, anemia, polyuria, polydipsia, isosthenuria, and growth retardation. Associations with extrarenal symptoms are frequent. In NPHPL1 patients, extrarenal symptoms include hypertension, essential tremor, sensorineural hearing loss and gout. Severely affected individuals can manifest a mitochondrial disorder with isolated complex I deficiency activity in muscle, seizures, mental retardation and hypertrophic dilated cardiomyopathy.
  • Sequence similarities
    Belongs to the peptidase M24B family.
  • Cellular localization
    Mitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • Aminopeptidase P3 antibody
    • APP3 antibody
    • NPHPL1 antibody
    • OTTHUMP00000199806 antibody
    • Probable Xaa Pro aminopeptidase 3 antibody
    • Probable Xaa-Pro aminopeptidase 3 antibody
    • X Pro aminopeptidase 3 antibody
    • X prolyl aminopeptidase (aminopeptidase P) 3 antibody
    • X-Pro aminopeptidase 3 antibody
    • XPNPEP3 antibody
    • XPP3_HUMAN antibody
    see all

Images

  • Immunohistochemical analysis of formalin fixed, paraffin embedded Human kidney tissue labeling XPNPEP3 with ab192826 at 7.5 µg/ml.

  • Anti-XPNPEP3 antibody (ab192826) at 1/500 dilution + A431 whole cell lysate at 30 µg

    Predicted band size : 57 kDa

    7.5% SDS PAGE

  • ab192896 (1:200 dilution) staining XPNPEP3 in paraformaldehyde-fixed A549 by ICC/IF (Immunocytochemistry/Immunofluorescence).  

References

ab192826 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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