Overview

  • Product name
  • Description
    Rabbit polyclonal to XPNPEP3
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant protein fragment containing a sequence corresponding to a region within amino acids 12 and 482 of XPNPEP3 (NP_071381).

  • Positive control
    • WB: A431 whole cell lysate; 293T, H1299, HepG2, MOLT4 and Raji cell lysates ICC/IF: A549 cells

Properties

Applications

Our Abpromise guarantee covers the use of ab95982 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 57 kDa.
ICC/IF 1/100 - 1/200.

Target

  • Tissue specificity
    Isoform 1 and isoform 2 are widely expressed, with isoform 1 being more abundant.
  • Involvement in disease
    Defects in XPNPEP3 are the cause of nephronophthisis-like nephropathy type 1 (NPHPL1) [MIM:613159]. A disorder with features of nephronophthisis, a cystic kidney disease leading to end-stage renal failure. Nephronophthisis is histologically characterized by modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts. Typical clinical manifestation are chronic renal failure, anemia, polyuria, polydipsia, isosthenuria, and growth retardation. Associations with extrarenal symptoms are frequent. In NPHPL1 patients, extrarenal symptoms include hypertension, essential tremor, sensorineural hearing loss and gout. Severely affected individuals can manifest a mitochondrial disorder with isolated complex I deficiency activity in muscle, seizures, mental retardation and hypertrophic dilated cardiomyopathy.
  • Sequence similarities
    Belongs to the peptidase M24B family.
  • Cellular localization
    Mitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • Aminopeptidase P3 antibody
    • APP3 antibody
    • NPHPL1 antibody
    • OTTHUMP00000199806 antibody
    • Probable Xaa Pro aminopeptidase 3 antibody
    • Probable Xaa-Pro aminopeptidase 3 antibody
    • X Pro aminopeptidase 3 antibody
    • X prolyl aminopeptidase (aminopeptidase P) 3 antibody
    • X-Pro aminopeptidase 3 antibody
    • XPNPEP3 antibody
    • XPP3_HUMAN antibody
    see all

Images

  • Anti-XPNPEP3 antibody (ab95982) at 1/500 dilution + A431 whole cell lysate at 30 µg

    Predicted band size : 57 kDa
  • Immunofluorescence analysis of XPNPEP3 in paraformaldehyde fixed A549, using ab95982 at 1/200 dilution. Lower image merged with DNA probe.

References

ab95982 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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