Anti-XRCC1 (phospho S461) antibody (ab84413)

Overview

  • Product name
    Anti-XRCC1 (phospho S461) antibody
    See all XRCC1 primary antibodies
  • Description
    Rabbit polyclonal to XRCC1 (phospho S461)
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) corresponding to a region surrounding Serine 461 of Human XRCC1 (P18887)

  • Positive control
    • Human breast adenocarcinoma; Mouse squamous cell carcinoma.

Properties

Applications

Our Abpromise guarantee covers the use of ab84413 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notes
    IHC-P: 1/100 - 1/500. Antigen retrieval with citrate buffer will enhance staining.
    Note: expected to work on frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
    • Sequence similarities
      Contains 2 BRCT domains.
    • Post-translational
      modifications
      Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.
      Sumoylated.
    • Cellular localization
      Nucleus. Accumulates at sites of DNA damage.
    • Information by UniProt
    • Database links
    • Alternative names
      • DNA repair protein XRCC1 antibody
      • RCC antibody
      • X ray repair complementing defective repair in chinese hamster antibody
      • X ray Repair Complementing Defective Repair in Chinese Hamster Cells antibody
      • X ray repair complementing defective repair in chinese hamster cells 1 antibody
      • X ray repair cross complementing 1 antibody
      • X ray repair cross complementing protein 1 antibody
      • X ray repair, complementing defective, repair in Chinese hamster antibody
      • X-ray repair cross-complementing protein 1 antibody
      • XRCC 1 antibody
      • Xrcc1 antibody
      • XRCC1_HUMAN antibody
      see all

    Images

    • Immunohistochemistry analysis of two serial sections of formalin-fixed, paraffin-embedded Human breast adenocarcinoma, using 1/250 ab84413 followed by DAB staining. Left panel: mock phosphatase treated; Right panel: calf intestinal phosphatase-treated.
    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Mouse squamous cell carcinoma, using 1/250 ab84413 followed DAB staining.

    References

    ab84413 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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