The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent dilution. Predicted molecular weight: 34 kDa.
FunctionInvolved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.
Sequence similaritiesBelongs to the RecA family. RAD51 subfamily.
Post-translational modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.
X ray repair complementing defective repair in Chinese hamster cells 2 antibody
X ray repair cross complementing protein 2 antibody
X-ray repair cross-complementing protein 2 antibody
References for Anti-XRCC2 antibody [XRCC2 1G4/1] (ab20253)
This product has been referenced in:
Xu K et al. XRCC2 rs3218536 polymorphism decreases the sensitivity of colorectal cancer cells to poly(ADP-ribose) polymerase 1 inhibitor. Oncol Lett8:1222-1228 (2014).
Read more (PubMed: 25120693) »
Gildemeister OS et al. Cellular redistribution of Rad51 in response to DNA damage: novel role for Rad51C. J Biol Chem284:31945-52 (2009).
Read more (PubMed: 19783859) »