Overview

  • Product nameAnti-XRN2 antibody
    See all XRN2 primary antibodies
  • Description
    Rabbit polyclonal to XRN2
  • Tested applicationsSuitable for: ELISA, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human, African Green Monkey
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide derived from an internal sequence of human XRN2.

  • Positive control
    • Human breast carcinoma tissue and COS7 cell extracts.

Properties

Applications

Our Abpromise guarantee covers the use of ab74799 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/5000.
WB 1/500 - 1/1000. Predicted molecular weight: 109 kDa.
IHC-P 1/50 - 1/100.

Target

  • RelevanceXRN2 possesses 5'->3' exoribonuclease activity. XRN2 shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The function of the human gene has not yet been determined, however, it may promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription.
  • Cellular localizationNucleus, nucleolus.
  • Database links
  • Alternative names
    • 5' 3' exoribonuclease 2 antibody
    • DHM1 like protein antibody
    • DHP protein antibody
    • XRN 2 antibody

Anti-XRN2 antibody images

  • ab74799 at 1/50 dilution staining XRN2 in human breast carcinoma by Immunohistochemistry, Paraffin-embedded tissue, in the absence or presence of the immunising peptide.
  • All lanes : Anti-XRN2 antibody (ab74799) at 1/500 dilution

    Lane 1 : COS7 cell extracts
    Lane 2 : COS7 cell extracts with immunising peptide at 10 µg

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 109 kDa
    Observed band size : 109 kDa
    Additional bands at : 40 kDa. We are unsure as to the identity of these extra bands.

References for Anti-XRN2 antibody (ab74799)

ab74799 has not yet been referenced specifically in any publications.

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