For the best experience on the Abcam website please upgrade to a modern browser such as
Storage instructions Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer Preservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, PBS (without Mg 2+ and Ca 2+), 150mM Sodium chloride, pH 7.4
Concentration information loading...
Purity Immunogen affinity purified
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/1000. Predicted molecular weight: 109 kDa.
1/50 - 1/100.
Relevance XRN2 possesses 5'->3' exoribonuclease activity. XRN2 shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The function of the human gene has not yet been determined, however, it may promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription.
Cellular localization Nucleus, nucleolus.
5' 3' exoribonuclease 2 antibody
DHM1 like protein antibody
DHP protein antibody
XRN 2 antibody
Anti-XRN2 antibody images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - XRN2 antibody (ab74799)
ab74799 at 1/50 dilution staining XRN2 in human breast carcinoma by Immunohistochemistry, Paraffin-embedded tissue, in the absence or presence of the immunising peptide.
Western blot - XRN2 antibody (ab74799)
All lanes : Anti-XRN2 antibody (ab74799) at 1/500 dilution Lane 1 : COS7 cell extracts Lane 2 : COS7 cell extracts with immunising peptide at 10 µg Lysates/proteins at 30 µg per lane. Predicted band size : 109 kDa Observed band size : 109 kDa Additional bands at : 40 kDa. We are unsure as to the identity of these extra bands.
References for Anti-XRN2 antibody (ab74799)
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"