Biological descriptionα2 Adrenoceptor agonist (IC50 = 68.2 nM). Ki values for receptor subtypes are 1570 (α2A), 1360 (α2B), 1200 (α2C) and 1460 nM (α2D). Activates KATP channels through the NO/cGMP pathway. Displays anaesthetic, antinociceptive and muscle relaxatory actions.
Chemical nameN-(2,6-Dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine hydrochloride
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Schwartz DD & Clark TP Affinity of detomidine, medetomidine and xylazine for alpha-2 adrenergic receptor subtypes. J Vet Pharmacol Ther21:107-11 (1998).
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Drew GM Pharmacological characterization of the presynaptic alpha-adrenoceptors regulating cholinergic activity in the guinea-pig ileum. Br J Pharmacol64:293-300 (1978).
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