Overview

  • Product name
  • Description
    Rabbit polyclonal to XYLT1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 551-600 (RITNWNRKLG CKCQYKHIVD WCGCSPNDFK PQDFHRFQQT ARPTFFARKF) of Human XYLT1 (NP_071449).

  • Positive control
    • PANC1 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab108263 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 108 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function
    Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes.
  • Tissue specificity
    Widely expressed. Expressed at higher level in placenta, kidney and pancreas. Weakly expressed in skeletal muscle.
  • Pathway
    Glycan metabolism; chondroitin sulfate biosynthesis.
    Glycan metabolism; heparan sulfate biosynthesis.
  • Sequence similarities
    Belongs to the glycosyltransferase 14 family. XylT subfamily.
  • Post-translational
    modifications
    Contains 7 disulfide bonds.
    N-glycosylated.
  • Cellular localization
    Endoplasmic reticulum membrane. Golgi apparatus membrane. Secreted. Some fraction is also found in the extracellular space together with chondroitin sulfate proteoglycans, suggesting that it can be secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Beta D xylosyltransferase 1 antibody
    • O xylosyltransferase 1 antibody
    • Peptide O-xylosyltransferase 1 antibody
    • PXYLT1 antibody
    • UDP-D-xylose:proteoglycan core protein antibody
    • XT-I antibody
    • XT1 antibody
    • XTI antibody
    • Xylosyltransferase 1 antibody
    • Xylosyltransferase I antibody
    • xylosyltransferase iota antibody
    • XylT-I antibody
    • XYLT1 antibody
    • XYLT1_HUMAN antibody
    see all

Images

  • Anti-XYLT1 antibody (ab108263) at 1 µg/ml + PANC1 cell lysate at 10 µg

    Predicted band size : 108 kDa

References

ab108263 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab108263.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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