Biological descriptionReversible soluble guanylyl cyclase activator (EC50 = 18.6 μM). NO-independent. Induces a concentration dependent increase in cGMP in vitro. Reduces blood-brain barrier permeability through HIF-1 inhibiton in vivo.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in ethanol to 50 mM and in DMSO to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Yan J et al. Differential effects of HIF-1 inhibition by YC-1 on the overall outcome and blood-brain barrier damage in a rat model of ischemic stroke. PLoS One6:e27798 (2011).
Read more (PubMed: 22110762) »
Pal B & Kitagawa T Binding of YC-1/BAY 41-2272 to soluble guanylate cyclase: A new perspective to the mechanism of activation. Biochem Biophys Res Commun397:375-9 (2010).
Read more (PubMed: 20513359) »
Mülsch A et al. Effect of YC-1, an NO-independent, superoxide-sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators. Br J Pharmacol120:681-9 (1997).
Read more (PubMed: 9051308) »