YEKL motif (clathrin AP-2 binding motif) (ab120380)

Overview

  • Product name
    YEKL motif (clathrin AP-2 binding motif)
  • Description
    Competes with AP-2 binding to NR2B
  • Biological description
    Peptide that competes with clathrin adaptor protein (AP-2) binding to NR2B, thought to be involved in synaptic regulation and internalisation of NMDA receptors. Contains the distal tyrosine motif of NR2B (YEKL) which acts as an internalisation motif. Induces a rapid increase in NMDA-mediated miniature post-synaptic currents in transfected cerebellar granule cells.

Properties

References

This product has been referenced in:
  • Prybylowski K  et al. The synaptic localization of NR2B-containing NMDA receptors is controlled by interactions with PDZ proteins and AP-2. Neuron 47:845-57 (2005). Read more (PubMed: 16157279) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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