YEKL motif (clathrin AP-2 binding motif) (ab120380)

Overview

  • Product nameYEKL motif (clathrin AP-2 binding motif)
  • Description
    Competes with AP-2 binding to NR2B
  • Biological descriptionPeptide that competes with clathrin adaptor protein (AP-2) binding to NR2B, thought to be involved in synaptic regulation and internalisation of NMDA receptors. Contains the distal tyrosine motif of NR2B (YEKL) which acts as an internalisation motif. Induces a rapid increase in NMDA-mediated miniature post-synaptic currents in transfected cerebellar granule cells.

Properties

    References for YEKL motif (clathrin AP-2 binding motif) (ab120380)

    This product has been referenced in:
    • Prybylowski K  et al. The synaptic localization of NR2B-containing NMDA receptors is controlled by interactions with PDZ proteins and AP-2. Neuron 47:845-57 (2005). Read more (PubMed: 16157279) »

    See 0 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab120380.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"