Overview

  • Product name
    YM-01 (YM-1)
  • Description
    Allosteric Hsp70 modulator. Potent anti-tau agent.
  • Alternative names
    • YM-1
  • Biological description
    Allosteric Hsp70 modulator. Potent anti-tau agent. MKT-077 analog. Promotes triage functions of Hsp70. Rapidly and potently reduces tau levels ex vivo. Shows antitumor effects in vivo.
  • Purity
    > 98%

Properties

  • Chemical name
    2-((Z)-((E)-3-Ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)-1-methylpyridin-1-ium chloride
  • Molecular weight
    417.97
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C20H20ClN3OS2
  • CAS Number
    409086-68-6
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in water to 5 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    [Cl-].C[n+]4ccccc4\C=C3/S/C(=C2/Sc1ccccc1N2C)C(=O)N3CC
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Colvin TA  et al. Hsp70-Bag3 interactions regulate cancer-related signaling networks. Cancer Res 74:4731-40 (2014). Read more (PubMed: 24994713) »
  • Wang AM  et al. Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation. Nat Chem Biol 9:112-8 (2013). Read more (PubMed: 23222885) »
  • Abisambra J  et al. Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. Biol Psychiatry 74:367-74 (2013). Read more (PubMed: 23607970) »

See 0 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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