Biological descriptionSelective α2 adrenoceptor antagonist (pKi values are 8.52, 8.00 and 9.17 for human α2A, α2B and α2C receptors, respectively).
Chemical name(16α,17α)-17-Hydroxyyohimban-16-carboxylic acid methyl ester hydrochloride
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 25 mM (with warming)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Doxey JC et al. Comparison of the alpha-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine. Naunyn Schmiedebergs Arch Pharmacol325:136-44 (1984).
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Goldberg MR & Robertson D Yohimbine: a pharmacological probe for study of the alpha 2-adrenoreceptor. Pharmacol Rev35:143-80 (1983).
Read more (PubMed: 6140686) »