Rabbit monoclonal [EPR11020] to YY1 associated factor 2
WB, IPmore details Unsuitable for:
ICC/IF or IHC-P
Human Predicted to work with:
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human YY1 associated factor 2 aa 100 to the C-terminus (Cysteine residue). The exact sequence is proprietary. Database link: Q8IY57
Human skeletal muscle and fetal heart lysates.
This product is a recombinant rabbit monoclonal antibody.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling.
Contains 1 RanBP2-type zinc finger.
Phosphorylated upon DNA damage, probably by ATM or ATR.
Western blot analysis on immunoprecipitation pellet from (1) Human skeletal muscle lysate or (2) 1X PBS (negative control) using ab177945 and HRP-conjugated anti-rabbit IgG preferentially detecting the non-reduced form of rabbit IgG.