Overview

  • Product name
    (Z)-4-Hydroxytamoxifen
  • Description
    Potent and selective estrogen receptor modulator
  • Alternative names
    • 4-OHT
  • Biological description

    Potent and selective estrogen receptor antagonist (IC50 = 7 nM). Active metabolite of (Z)-tamoxifen (ab120656) and exhibits higher potency in vitro. Shows antiproliferative effect (IC50 = 27 μM). Induces p21 nuclear localization.

  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Mürdter TE  et al. Activity levels of tamoxifen metabolites at the estrogen receptor and the impact of genetic polymorphisms of phase I and II enzymes on their concentration levels in plasma. Clin Pharmacol Ther 89:708-17 (2011). Read more (PubMed: 21451508) »
  • Seeger H  et al. Inhibition of human breast cancer cell proliferation with estradiol metabolites is as effective as with tamoxifen. Horm Metab Res 36:277-80 (2004). Read more (PubMed: 15156405) »
  • Malet C  et al. Tamoxifen and hydroxytamoxifen isomers versus estradiol effects on normal human breast cells in culture. Cancer Res 48:7193-9 (1988). Read more (PubMed: 3056610) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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