Overview

  • Product nameAnti-ZAK antibody
    See all ZAK primary antibodies
  • Description
    Mouse monoclonal to ZAK
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-456 of Human ZAK (isoform 2 of Q9NYL2)

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • IsotypeIgG2b
  • Light chain typekappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab57318 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionStress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28'.
    • Tissue specificityUbiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed.
    • Sequence similaritiesBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
      Contains 1 protein kinase domain.
      Contains 1 SAM (sterile alpha motif) domain.
    • Cellular localizationCytoplasm. Nucleus. Translocates to the nucleus upon ultraviolet B irradiation.
    • Information by UniProt
    • Database links
    • Alternative names
      • AZK antibody
      • Cervical cancer suppressor gene 4 protein antibody
      • HCCS 4 antibody
      • HCCS-4 antibody
      • HCCS4 antibody
      • Human cervical cancer suppressor gene 4 protein antibody
      • Leucine zipper and sterile alpha motif containing kinase antibody
      • Leucine zipper- and sterile alpha motif-containing kinase antibody
      • Mitogen activated protein kinase kinase kinase MLT antibody
      • Mitogen-activated protein kinase kinase kinase MLT antibody
      • Mixed lineage kinase 7 antibody
      • Mixed lineage kinase related kinase antibody
      • Mixed lineage kinase related kinase MRK beta antibody
      • Mixed lineage kinase with a leucine zipper and a sterile alpha motif antibody
      • Mixed lineage kinase-related kinase antibody
      • MLK 7 antibody
      • MLK like mitogen activated protein triple kinase antibody
      • MLK related kinase antibody
      • MLK-like mitogen-activated protein triple kinase antibody
      • MLK-related kinase antibody
      • MLK7 antibody
      • Mlklak antibody
      • MLT antibody
      • MLTK_HUMAN antibody
      • MRK antibody
      • Sterile alpha motif and leucine zipper containing kinase AZK antibody
      • Sterile alpha motif- and leucine zipper-containing kinase AZK antibody
      • Zak antibody
      see all

    Anti-ZAK antibody images

    • Western blot against tagged recombinant protein immunogen using ab57318 ZAK antibody at 1ug/ml. Predicted band size of immunogen is 76 kDa

    References for Anti-ZAK antibody (ab57318)

    ab57318 has not yet been referenced specifically in any publications.

    Product Wall

    Merci de nous avoir contactés.

    Après vérification auprès du laboratoire, je vous confirme que l'anti-ZAK ab57318a été produit en utilisant l'isoforme 2 (ou la forme beta) de la ZAK humaine dont la s&ea...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"