Overview

  • Product nameAnti-ZAK antibody
    See all ZAK primary antibodies
  • Description
    Rabbit polyclonal to ZAK
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment, corresponding to amino acids 36-264 of Human ZAK (BC001401).

  • Positive control
    • HeLa, Human Fetal Lymph

Properties

  • FormLyophilised:Reconstitute with 200ul distilled sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein A purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab99933 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 91 kDa.
IHC-P 1/100 - 1/500.

Target

  • FunctionStress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28'.
  • Tissue specificityUbiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed.
  • Sequence similaritiesBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
    Contains 1 protein kinase domain.
    Contains 1 SAM (sterile alpha motif) domain.
  • Cellular localizationCytoplasm. Nucleus. Translocates to the nucleus upon ultraviolet B irradiation.
  • Information by UniProt
  • Database links
  • Alternative names
    • AZK antibody
    • Cervical cancer suppressor gene 4 protein antibody
    • HCCS 4 antibody
    • HCCS-4 antibody
    • HCCS4 antibody
    • Human cervical cancer suppressor gene 4 protein antibody
    • Leucine zipper and sterile alpha motif containing kinase antibody
    • Leucine zipper- and sterile alpha motif-containing kinase antibody
    • Mitogen activated protein kinase kinase kinase MLT antibody
    • Mitogen-activated protein kinase kinase kinase MLT antibody
    • Mixed lineage kinase 7 antibody
    • Mixed lineage kinase related kinase antibody
    • Mixed lineage kinase related kinase MRK beta antibody
    • Mixed lineage kinase with a leucine zipper and a sterile alpha motif antibody
    • Mixed lineage kinase-related kinase antibody
    • MLK 7 antibody
    • MLK like mitogen activated protein triple kinase antibody
    • MLK related kinase antibody
    • MLK-like mitogen-activated protein triple kinase antibody
    • MLK-related kinase antibody
    • MLK7 antibody
    • Mlklak antibody
    • MLT antibody
    • MLTK_HUMAN antibody
    • MRK antibody
    • Sterile alpha motif and leucine zipper containing kinase AZK antibody
    • Sterile alpha motif- and leucine zipper-containing kinase AZK antibody
    • Zak antibody
    see all

Anti-ZAK antibody images

  • Anti-ZAK antibody (ab99933) at 1/500 dilution + HeLa Cell Lysate

    Predicted band size : 91 kDa
  • Staining of Human ZAK in a Formalin/PFA-fixed paraffin-embedded section of Human Fetal Lymph using ab99933 at a dilution of 1/100.

References for Anti-ZAK antibody (ab99933)

ab99933 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"