Overview

  • Product nameAnti-ZC3H12D antibody
    See all ZC3H12D primary antibodies
  • Description
    Rabbit polyclonal to ZC3H12D
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A 16 amino acid peptide from the intermediate residues of Human ZC3H12D protein (NP_997243).

  • Positive control
    • WB: Fetal small intestine lysate and fetal spleen lystae IHC-P: Fetal small intestine

Properties

Applications

Our Abpromise guarantee covers the use of ab100862 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 58 kDa.
IHC-P Use at an assay dependent concentration.

Target

  • FunctionMay regulate cell growth likely by suppressing RB1 phosphorylation (PubMed:19531561). May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages (PubMed:26134560). Serve as a tumor suppressor in certain leukemia cells (PubMed:17210687). Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation (PubMed:19531561).
  • Tissue specificityExpressed in normal human lymphocytes but defective in some leukemia/lymphoma cell lines.
  • Involvement in diseaseA chromosomal aberration involving ZC3H12D may be the cause of the transformation of follicular lymphoma (FL) to diffuse large B-cell lymphoma (DLBCL). Translocation t(2;6)(p12;q25) with IGK. Resulting protein may not be expressed.
  • Sequence similaritiesBelongs to the ZC3H12 family.
    Contains 1 C3H1-type zinc finger.
  • Cellular localizationCytoplasm. Nucleus; Cytoplasm. Localized as discrete granules. Colocalized with mRNA-processing body markers, AGO2 and DCP1A, but not with a stress granule maker, TIA1, in the cytoplasm and Cytoplasm, P-body. Colocalizes with ZC3H12A in GW bodies (GWBs) (PubMed:26134560).
  • Information by UniProt
  • Database links
  • Alternative names
    • C6orf95 antibody
    • ZC3H12D antibody
    • FLJ00361 antibody
    • FLJ46041 antibody
    • MCP induced protein 4 antibody
    • MCP-induced protein 4 antibody
    • MCPIP4 antibody
    • p34 antibody
    • Probable ribonuclease ZC3H12D antibody
    • TFL antibody
    • Transformed follicular lymphoma antibody
    • Tumor suppressor TFL antibody
    • ZC12D_HUMAN antibody
    • ZC3H12D antibody
    • Zinc finger CCCH domain containing protein 12D antibody
    • Zinc finger CCCH domain-containing protein 12D antibody
    see all

Anti-ZC3H12D antibody images

  • All lanes : Anti-ZC3H12D antibody (ab100862) at 1/500 dilution

    Lane 1 : Human fetal small intestine lysate
    Lane 2 : Human fetal spleen lysate


    Predicted band size : 58 kDa
    Observed band size : 57 kDa (why is the actual band size different from the predicted?)
  • ab100862, at a 1/100 dilution, staining ZC3H12D in formalin-fixed, paraffin-embedded Human fetal small intestine tissue, showing cytoplasmic staining, by Immunohistochemistry.

References for Anti-ZC3H12D antibody (ab100862)

This product has been referenced in:
  • Huang S  et al. The putative tumor suppressor Zc3h12d modulates toll-like receptor signaling in macrophages. Cell Signal : (2011). IHC-P ; Mouse . Read more (PubMed: 22036805) »

See 1 Publication for this product

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