Overview

  • Product nameAnti-ZCCHV antibody
    See all ZCCHV primary antibodies
  • Description
    Rabbit polyclonal to ZCCHV
  • Specificityab105357 is predicted to not crossreact with other ZAP members. Four isoforms of ZCCHV are known to exist.
  • Tested applicationsSuitable for: ICC/IF, WB, ICCmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A 14 amino acid synthetic peptide near the C terminus of Human ZCCHV (NP_078901).

  • Positive control
    • WB: HeLa cell lysate ICC: HeLa cells

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab105357 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 101 kDa.
ICC Use a concentration of 20 µg/ml.

Target

  • FunctionInduces an innate immunity to viral infections by preventing the accumulation of viral RNAs in the cytoplasm. Seems to recruit the RNA processing exosome to degrade the target RNAs. Inhibits alphavirus and filovirus replication.
  • Sequence similaritiesContains 4 C3H1-type zinc fingers.
    Contains 1 PARP catalytic domain.
    Contains 1 WWE domain.
  • DomainThe second and fourth zinc fingers are involved in binding to specific viral RNAs.
  • Cellular localizationCytoplasm. Nucleus. Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner.
  • Information by UniProt
  • Database links
  • Alternative names
    • ADP ribosyltransferase diphtheria toxin like 13 antibody
    • ARTD13 antibody
    • FLB6421 antibody
    • PARP13 antibody
    • ZAP antibody
    • ZC3H2 antibody
    • ZC3HAV 1 antibody
    • Zc3hav1 antibody
    • ZC3HDC 2 antibody
    • ZC3HDC2 antibody
    • ZCCHV_HUMAN antibody
    • Zinc finger antiviral protein antibody
    • Zinc finger CCCH domain containing protein 2 antibody
    • Zinc finger CCCH domain-containing antiviral protein 1 antibody
    • Zinc finger CCCH domain-containing protein 2 antibody
    • Zinc finger CCCH type antiviral 1 antibody
    • Zinc finger CCCH type antiviral protein 1 antibody
    • Zinc finger CCCH-type antiviral protein 1 antibody
    see all

Anti-ZCCHV antibody images

  • Anti-ZCCHV antibody (ab105357) at 1 µg/ml + HeLa cell lysate at 15 µg

    Predicted band size : 101 kDa
  • Immunocytochemical analysis of ZCCHV in HeLa cells stained with ab105357 at 20 µg/ml.
  • Immunofluorescence of ZC3HAV1 in Hela cells using ab105357 at 20 ug/ml.

References for Anti-ZCCHV antibody (ab105357)

This product has been referenced in:
  • Lee H  et al. Zinc-finger antiviral protein mediates retinoic acid inducible gene I-like receptor-independent antiviral response to murine leukemia virus. Proc Natl Acad Sci U S A 110:12379-84 (2013). Read more (PubMed: 23836649) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"