• Product nameAnti-ZCH11 antibody
    See all ZCH11 primary antibodies
  • Description
    Rabbit polyclonal to ZCH11
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide, corresponding to a region within internal sequence amino acids 1403-1452 (GSAQQQGDQS IRTRQSSECS ESPSYSPQPQ PFPQNSSQSA AITQPSSQPG) of Human ZCH11 (NP_001009881.1).

  • Positive control
    • ACHN cell lysate



Our Abpromise guarantee covers the use of ab118917 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.2 - 1 µg/ml. Predicted molecular weight: 185 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • FunctionUridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B. Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation.
  • Sequence similaritiesBelongs to the DNA polymerase type-B-like family.
    Contains 3 CCHC-type zinc fingers.
    Contains 2 PAP-associated domains.
  • Post-translational
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationNucleus. Cytoplasm. Translocates into the cytoplasm following treatment of the cell with LPS.
  • Information by UniProt
  • Database links
  • Alternative names
    • DKFZp779C1943 antibody
    • EC antibody
    • FLJ42878 antibody
    • KIAA0191 antibody
    • PAP associated domain containing 3 antibody
    • PAPD3 antibody
    • Terminal uridylyltransferase 4 antibody
    • TUT4 antibody
    • TUT4_HUMAN antibody
    • TUTase 4 antibody
    • ZCCHC 11 antibody
    • Zcchc11 antibody
    • Zinc finger CCHC domain containing 11 antibody
    • Zinc finger CCHC domain containing protein 11 antibody
    • Zinc finger CCHC domain-containing protein 11 antibody
    see all

Anti-ZCH11 antibody images

  • Anti-ZCH11 antibody (ab118917) at 1 µg/ml + ACHN cell lysate at 10 µg

    Predicted band size : 185 kDa

References for Anti-ZCH11 antibody (ab118917)

ab118917 has not yet been referenced specifically in any publications.

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I am sorry about the issues you were having with ab118917 in western blot. As we discussed I am sending a vial of ab96155 as a free of charge replacement. Your new order number is ***.

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