• Product name
  • Description
    Rabbit polyclonal to Zic1
  • Specificity
    ab72694 detects endogenous levels of total Zic1 protein.
  • Tested applications
    Suitable for: ICC/IF, WB, ELISA, IHC-P, IHC-Frmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide derived from an internal sequence of human Zic1

  • Positive control
    • Jurkat and COLO cell extracts. Paraffin embedded human brain tissue.



Our Abpromise guarantee covers the use of ab72694 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use at an assay dependent concentration. PubMed: 20713527
WB 1/500 - 1/1000. Detects a band of approximately 48 kDa (predicted molecular weight: 48 kDa).
ELISA 1/20000.
IHC-P 1/50 - 1/100.
IHC-Fr Use at an assay dependent concentration. PubMed: 23603813


  • Function
    Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'.
  • Tissue specificity
    CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined.
  • Sequence similarities
    Belongs to the GLI C2H2-type zinc-finger protein family.
    Contains 5 C2H2-type zinc fingers.
  • Domain
    The C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation.
  • Cellular localization
    Nucleus. Cytoplasm. Localizes in the cytoplasm in presence of MDFIC overexpression.
  • Information by UniProt
  • Database links
  • Alternative names
    • Odd paired homolog Drosophila antibody
    • Zic 1 antibody
    • ZIC antibody
    • Zic family member 1 (odd-paired Drosophila homolog) antibody
    • Zic family member 1 antibody
    • Zic protein member 1 antibody
    • zic1 antibody
    • ZIC1_HUMAN antibody
    • Zinc finger protein 201 antibody
    • Zinc finger protein of the cerebellum 1 antibody
    • Zinc finger protein ZIC 1 antibody
    • Zinc finger protein ZIC1 antibody
    • ZNF 201 antibody
    • ZNF201 antibody
    see all


  • All lanes : Anti-Zic1 antibody (ab72694) at 1/500 dilution

    Lane 1 : Jurkat cell extract
    Lane 2 : COLO cell extract
    Lane 3 : Jurkat cell extract with immunising peptide at 5 µg

    Lysates/proteins at 5 µg per lane.

    Predicted band size : 48 kDa
    Observed band size : 48 kDa
  • ab72694 at 1/50 dilution staining Zic1 in human brain by Immunohistochemistry, Paraffin-embedded tissue, in the absence or presence of the immunising peptide.


This product has been referenced in:
  • Petroni M  et al. The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress. Cell Death Differ 23:197-206 (2016). WB ; Human . Read more (PubMed: 26068589) »
  • Fernández-Santiago R  et al. Aberrant epigenome in iPSC-derived dopaminergic neurons from Parkinson's disease patients. EMBO Mol Med 7:1529-46 (2015). Read more (PubMed: 26516212) »

See all 6 Publications for this product

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