Overview

  • Product nameAnti-Zic2 antibody
    See all Zic2 primary antibodies
  • Description
    Mouse monoclonal to Zic2
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant tagged fragment (Human)

Properties

Applications

Our Abpromise guarantee covers the use of ab61278 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notesELISA: Use at an assay dependent dilution.
    WB: Use at a concentration of 1 - 5 µg/ml. Predicted molecular weight: 55 kDa.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionActs as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos.
    • Involvement in diseaseDefects in ZIC2 are a cause of holoprosencephaly type 5 (HPE5) [MIM:609637]. A structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. Although severe facial anomalies are common in HPE, patients with ZINC2 mutations have relatively normal faces.
    • Sequence similaritiesBelongs to the GLI C2H2-type zinc-finger protein family.
      Contains 5 C2H2-type zinc fingers.
    • DomainThe C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation.
    • Post-translational
      modifications
      Phosphorylated.
      Ubiquitinated by RNF180, leading to its degradation.
    • Cellular localizationNucleus. Cytoplasm. Localizes in the cytoplasm in presence of MDFIC overexpression. Both phosphorylated and unphosphorylated forms are localized in the nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • HPE 5 antibody
      • HPE5 antibody
      • Odd paired homolog Drosophila antibody
      • Zic 2 antibody
      • Zic family member 2 (odd paired Drosophila homolog) antibody
      • Zic family member 2 antibody
      • ZIC2 antibody
      • ZIC2_HUMAN antibody
      • Zinc finger protein of the cerebellum 2 antibody
      • Zinc finger protein ZIC 2 antibody
      • Zinc finger protein Zic2 antibody
      see all

    Anti-Zic2 antibody images



    • Predicted band size : 55 kDa

    References for Anti-Zic2 antibody (ab61278)

    ab61278 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"