Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab58318 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionActs as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.
    • Involvement in diseaseHeterotaxy, visceral, 1, X-linked
      VACTERL association X-linked with or without hydrocephalus
      Congenital heart defects, multiple types, 1, X-linked
    • Sequence similaritiesBelongs to the GLI C2H2-type zinc-finger protein family.
      Contains 5 C2H2-type zinc fingers.
    • DomainThe C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation.
    • Cellular localizationNucleus. Cytoplasm. Localizes in the cytoplasm in presence of MDFIC overexpression (By similarity). Translocation to the nucleus requires KPNA1 or KPNA6.
    • Information by UniProt
    • Database links
    • Alternative names
      • Heterotaxy 1 antibody
      • HTX antibody
      • HTX1 antibody
      • ZIC 3 antibody
      • Zic family member 3 (odd paired Drosophila homolog heterotaxy 1) antibody
      • Zic family member 3 antibody
      • Zic3 antibody
      • ZIC3_HUMAN antibody
      • Zinc finger protein 203 antibody
      • Zinc finger protein of the cerebellum 3 antibody
      • Zinc finger protein ZIC 3 (Zinc finger protein of the cerebellum 3) antibody
      • Zinc finger protein ZIC 3 antibody
      • ZNF203 antibody
      see all

    Anti-ZIC3 antibody images

    • Western blot against tagged recombinant protein immunogen using ab58318 Zic 3 antibody at 1ug/ml. Predicted band size of immunogen is 36 kDa

    References for Anti-ZIC3 antibody (ab58318)

    ab58318 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"