Overview

  • Product name
    ZIP
  • Description
    Novel, cell-permeable protein kinase Mζ (PKMζ) inhibitor
  • Alternative names
    • z-Pseudosubstrate inhibitory peptide
  • Biological description
    Novel, cell-permeable PKMζ inhibitor, a constitutively active, atypical PKC isozyme. Efficacious in in vitro and in vivo models of synaptic plasticity (IC50 = 1 - 2.5 μM).
  • Purity
    > 94%

Properties

  • Molecular weight
    1928.40
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C90H154N30O17
  • CAS Number
    863987-12-6
  • Sequence
    SIYRRGARRWRKL (Modifications: N-terminal myristyl)
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

  • Research areas

    References for ZIP (ab120993)

    This product has been referenced in:
    • Wu-Zhang AX  et al. Cellular pharmacology of protein kinase M? (PKM?) contrasts with its in vitro profile: implications for PKM? as a mediator of memory. J Biol Chem 287:12879-85 (2012). Read more (PubMed: 22378786) »
    • Cai D  et al. Protein kinase M maintains long-term sensitization and long-term facilitation in aplysia. J Neurosci 31:6421-31 (2011). Read more (PubMed: 21525283) »
    • Serrano P  et al. Persistent phosphorylation by protein kinase Mzeta maintains late-phase long-term potentiation. J Neurosci 25:1979-84 (2005). Read more (PubMed: 15728837) »

    See 0 Publications for this product

    Product Wall



    Generally, we check all vials after freeze drying to satisfy ourselves that there is product in the vial, but it isn’t always possible to see a nice fluffy plug of material in the bottom of the vial; sometimes the result is a thin film ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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