ZIP, protein kinase Czeta (PKC-zeta) inhibitor (ab120993)
Key features and details
- Novel, cell-permeable protein kinase Cζ (PKCζ) inhibitor
- CAS Number: 863987-12-6
- Purity: > 94%
- Soluble in water
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
ZIP, protein kinase Czeta (PKC-zeta) inhibitor -
Description
Novel, cell-permeable protein kinase Cζ (PKCζ) inhibitor -
Alternative names
- z-Pseudosubstrate inhibitory peptide
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Biological description
Novel, cell-permeable PKCζ inhibitor, a constitutively active, atypical PKM isozyme. Efficacious in in vitro and in vivo models of synaptic plasticity (IC50 = 1 - 2.5 μM).
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Purity
> 94% -
CAS Number
863987-12-6 -
Chemical structure
Properties
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Molecular weight
1928.40 -
Molecular formula
C90H154N30O17 -
Sequence
SIYRRGARRWRKL (Modifications: N-terminal myristyl) -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (4)
ab120993 has been referenced in 4 publications.
- Tan J et al. Insulin Resistance Triggers Atherosclerosis: Caveolin 1 Cooperates with PKCzeta to Block Insulin Signaling in Vascular Endothelial Cells. Cardiovasc Drugs Ther N/A:N/A (2023). PubMed: 37289375
- Lim J et al. Piezoelectric effect stimulates the rearrangement of chondrogenic cells and alters ciliary orientation via atypical PKC?. Biochem Biophys Rep 30:101265 (2022). PubMed: 35540436
- Guan L et al. Contribution of Amygdala Histone Acetylation in Early Life Stress-Induced Visceral Hypersensitivity and Emotional Comorbidity. Front Neurosci 16:843396 (2022). PubMed: 35600618
- Lee A et al. Amino acid-based compound activates atypical PKC and leptin receptor pathways to improve glycemia and anxiety like behavior in diabetic mice. Biomaterials 239:119839 (2020). PubMed: 32065973