Overview

  • Product name
    ZM 241385
  • Description
    Potent, selective A2A antagonist
  • Biological description
    Potent A2 adenosine receptor antagonist, with approx 50-fold selectivity for A2A receptors. (Ki values are <1 nM, 50 nM, 255 nM and >10 μM at human cloned A2A, A2B, A1 and A3 receptors, respectively). Orally active in vivo.
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Orru M  et al. Striatal pre- and postsynaptic profile of adenosine A(2A) receptor antagonists. PLoS One 6:e16088 (2011). Read more (PubMed: 21264319) »
  • Ongini E  et al. Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol 359:7-10 (1999). Read more (PubMed: 9933143) »
  • Keddie JR  et al. In vivo characterisation of ZM 241385, a selective adenosine A2A receptor antagonist. Eur J Pharmacol 301:107-13 (1996). Read more (PubMed: 8773453) »
  • Poucher SM  et al. The in vitro pharmacology of ZM 241385, a potent, non-xanthine A2a selective adenosine receptor antagonist. Br J Pharmacol 115:1096-102 (1995). Read more (PubMed: 7582508) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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