Overview

  • Product name
  • Description
    Rabbit polyclonal to ZNF521
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    C-Terminus of human ZNF521

  • Positive control
    • Human Kidney and Small Intestine tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab113835 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml.

Target

  • Function
    Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes.
  • Tissue specificity
    Predominantly expressed in hematopoietic cells. Present in organs and tissues that contain stem and progenitor cells, myeloid and/or lymphoid: placenta, spleen, lymph nodes, thymus, bone marrow and fetal liver. Within the hematopoietic system, it is abundant in CD34(+) cells but undetectable in mature peripheral blood leukocytes, and its levels rapidly decrease during the differentiation of CD34(+) cells in response to hemopoietins.
  • Involvement in disease
    Note=A chromosomal aberration involving ZNF521 is found in acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with PAX5. The translocation generates the PAX5-ZNF521 oncogene consisting of the N-terminus part of PAX5 and the C-terminus part of ZNF521.
  • Sequence similarities
    Belongs to the krueppel C2H2-type zinc-finger protein family.
    Contains 30 C2H2-type zinc fingers.
  • Domain
    Uses different DNA- and protein-binding zinc fingers to regulate the distinct BMP-Smad and hematopoietic system.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • B930086A16Rik antibody
    • DKFZp564D0764 antibody
    • Early hematopoietic zinc finger antibody
    • Early hematopoietic zinc finger protein antibody
    • EHZF antibody
    • Evi3 antibody
    • LYST-interacting protein 3 antibody
    • MGC142182 antibody
    • MGC142208 antibody
    • Zfp521 antibody
    • Zinc finger protein 521 antibody
    • ZN521_HUMAN antibody
    • Znf521 antibody
    see all

Images

  • ab113835, at 5µg/ml, staining ZNF521 in formalin-fixed, paraffin-embedded Human Small Intestine tissue by Immunohistochemistry.
  • ab113835, at 5µg/ml, staining ZNF521 in formalin-fixed, paraffin-embedded Human Kidney tissue by Immunohistochemistry.

References

ab113835 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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