Overview

  • Product name
  • Description
    Rabbit polyclonal to ZNF750
  • Tested applications
    Suitable for: IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence, corresponding to C terminal amino acids 621-721 of Human ZNF750.

  • Positive control
    • Human vagina tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab121685 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 1 - 4 µg/ml.

Recommend PFA Fixation and Triton X-100 treatment

Target

  • Tissue specificity
    Expressed in the skin, prostate, lung, placenta and thymus, and at low level in T-cells. Not expressed in peripheral blood leukocytes, pancreas and brain. Clearly expressed in primary keratinocytes but not in fibroblasts.
  • Involvement in disease
    Defects in ZNF750 are the cause of Seborrhea-like dermatitis with psoriasiform (SLDP) [MIM:610227]. SLDP is characterized by a chronic fine diffuse scaly erythematous rash on the face, particularly on the chin, nasolabial folds and eyebrows, around earlobes and over the scalp. The rash exacerbate in the winter, with emotional stress and after strenuous physical activity. Hyperkeratosis of skin over the elbows, knees, palms, soles and metacarpophalangeal joints is evident. There is no arthralgia, arthritis or neurological disorders.
  • Information by UniProt
  • Database links
  • Alternative names
    • Protein ZNF750 antibody
    • ZFP750 antibody
    • Zinc finger protein 750 antibody
    • ZN750_HUMAN antibody
    • ZNF750 antibody
    see all

Images

  • Immunofluorescent staining of Human cell line U-251MG shows positivity in nucleus and vesicles. Recommended concentration of ab121685 1-4 µg/ml. Cells treated with PFA/Triton X-100.
  • ab121685 at 1/25 dilution staining ZNF750 in Paraffin-embedded Human Vagina tissue by Immunohistochemistry.

References

ab121685 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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