Overview

  • Product name
  • Description
    Rabbit polyclonal to ZSWIM2
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human ZSWIM2 (internal sequence). The exact sequence is proprietary.
    Database link: Q8NEG5

  • Positive control
    • WB: NTERA-2 cl.D1 [NT2/D1] whole cell lysate. IHC-P: Human hepatoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab227453 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/1000.
WB 1/500 - 1/3000. Predicted molecular weight: 73 kDa.

Target

  • Function
    E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes.
  • Sequence similarities
    Contains 2 RING-type zinc fingers.
    Contains 1 SWIM-type zinc finger.
    Contains 1 ZZ-type zinc finger.
  • Domain
    The SWIM-type zinc finger is reqiered for ubiquitination activity.
  • Post-translational
    modifications
    Polyubiquitinated. Polyubiquitination is followed by degradation via the proteasome.
  • Information by UniProt
  • Database links
  • Alternative names
    • E3 ubiquitin-protein ligase ZSWIM2 antibody
    • MEKK1-related protein X antibody
    • MEX antibody
    • MGC33890 antibody
    • Zinc finger SWIM domain containing 2 antibody
    • Zinc finger SWIM domain containing protein 2 antibody
    • Zinc finger SWIM domain-containing protein 2 antibody
    • Zinc finger SWIM type containing 2 antibody
    • ZSWIM2 antibody
    • ZSWM2_HUMAN antibody
    • ZZ type zinc finger containing protein 2 antibody
    • ZZ-type zinc finger-containing protein 2 antibody
    • ZZZ2 antibody
    see all

Images

  • Anti-ZSWIM2 antibody (ab227453) at 1/1000 dilution + NTERA-2 cl.D1 [NT2/D1] (human malignant pluripotent embryonic carcinoma cell line) whole cell lysate at 30 µg

    Predicted band size: 73 kDa



    7.5% SDS-PAGE gel.

  • Paraffin-embedded human hepatoma tissue stained for ZSWIM2 using ab227453 at 1/500 dilution in immunohistochemical analysis.

References

ab227453 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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