Key features and details
- GABAA antagonist
- CAS Number: 40709-69-1
- Purity: > 99%
- Soluble in water to 10 mM
- Form / State: Solid
- Source: Synthetic
Product name(-)-Bicuculline methiodide, GABAA antagonist
Chemical name[S-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide
Storage instructionsStore at +4°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 10 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
To be used on the same day after reconstitution.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120108 has been referenced in 25 publications.
- Booker SA et al. Presynaptic GABAB receptors functionally uncouple somatostatin interneurons from the active hippocampal network. Elife 9:N/A (2020). PubMed: 32073397
- Davenport EC et al. Autism and Schizophrenia-Associated CYFIP1 Regulates the Balance of Synaptic Excitation and Inhibition. Cell Rep 26:2037-2051.e6 (2019). PubMed: 30784587
- Li DB et al. Reevaluating the ability of cerebellum in associative motor learning. Sci Rep 9:6029 (2019). PubMed: 30988338
- Bohannon AS & Hablitz JJ Developmental Changes in HCN Channel Modulation of Neocortical Layer 1 Interneurons. Front Cell Neurosci 12:20 (2018). PubMed: 29440994
- Hardy D et al. The role of calretinin-expressing granule cells in olfactory bulb functions and odor behavior. Sci Rep 8:9385 (2018). PubMed: 29925844