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(-)-Bicuculline methiodide (mM/ml), GABAA antagonist (ab144491)

  • Datasheet
  • SDS
  • COA
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Key features and details

  • GABAA antagonist. 1 ml water soluble pack.
  • CAS Number: 40709-69-1
  • Purity: > 99%
  • Soluble in 1 ml water to give specified mM/ml concentration
  • Form / State: Solid
  • Source: Synthetic

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Overview

  • Product name

    (-)-Bicuculline methiodide (mM/ml), GABAA antagonist
  • Description

    GABAA antagonist. 1 ml water soluble pack.
  • Biological description

    Water-soluble GABAA antagonist. Methiodide salt of (+)-bicuculline (ab120107). Actions on neuronal Ca2+-activated K+ channels reported.

    Soluble in 1 ml water to give specified mM/ml concentration.

  • Purity

    > 99%
  • CAS Number

    40709-69-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [S-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide
  • Molecular weight

    509.29
  • Molecular formula

    C21H20INO6
  • PubChem identifier

    185826
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in 1 ml water to give specified mM/ml concentration
  • Handling

    This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    [I-].C[N+]5(C)CCc1cc6OCOc6cc1[C@@H]5[C@H]4OC(=O)c3c4ccc2OCOc23
  • Source

    Synthetic

  • Research areas

    • Biochemicals
    • Product Range
    • Stock Solutions

Associated products

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
    • SDS
    • COA
  • References (6)

    Publishing research using ab144491? Please let us know so that we can cite the reference in this datasheet.

    ab144491 has been referenced in 6 publications.

    • Glasgow SD & Chapman CA Muscarinic depolarization of layer II neurons of the parasubiculum. PLoS One 8:e58901 (2013). PubMed: 23520542
    • Haam J  et al. GABA is excitatory in adult vasopressinergic neuroendocrine cells. J Neurosci 32:572-82 (2012). PubMed: 22238092
    • Platt NJ  et al. Striatal dopamine transmission is subtly modified in human A53Ta-synuclein overexpressing mice. PLoS One 7:e36397 (2012). PubMed: 22570709
    • Threlfell S  et al. Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons. Neuron 75:58-64 (2012). PubMed: 22794260
    • Blum R  et al. Neuronal network formation from reprogrammed early postnatal rat cortical glial cells. Cereb Cortex 21:413-24 (2011). PubMed: 20562320
    • Jeong HJ  et al. N-arachidonyl-glycine modulates synaptic transmission in superficial dorsal horn. Br J Pharmacol 161:925-35 (2010). PubMed: 20860669

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