(-)-Bicuculline methiodide (mM/ml), GABAA antagonist (ab144491)

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Overview

  • Product name

    (-)-Bicuculline methiodide (mM/ml), GABAA antagonist

  • Description

    GABAA antagonist. 1 ml water soluble pack.

  • Biological description

    Water-soluble GABAA antagonist. Methiodide salt of (+)-bicuculline (ab120107). Actions on neuronal Ca2+-activated K+ channels reported.

    Soluble in 1 ml water to give specified mM/ml concentration.

  • Purity

    > 99%

  • CAS Number

    55950-07-7

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [S-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide

  • Molecular weight

    509.29

  • Molecular formula

    C21H20INO6

  • PubChem identifier

    185826

  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.

  • Solubility overview

    Soluble in 1 ml water to give specified mM/ml concentration

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    [I-].C[N+]5(C)CCc1cc6OCOc6cc1[C@@H]5[C@H]4OC(=O)c3c4ccc2OCOc23

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Seutin V & Johnson SW Recent advances in the pharmacology of quaternary salts of bicuculline. Trends Pharmacol Sci 20:268-70 (1999). Read more (PubMed: 10390643) »
  • Olsen RW  et al. Studies on the neuropharmacological activity of bicuculline and related compounds. Brain Res 102:283-99 (1976). Read more (PubMed: 1247886) »
See all 6 Publications for this product

Publishing research using ab144491? Please let us know so that we can cite the reference in this datasheet.

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