Key features and details
- GABAA antagonist. 1 ml water soluble pack.
- CAS Number: 40709-69-1
- Purity: > 99%
- Soluble in 1 ml water to give specified mM/ml concentration
- Form / State: Solid
- Source: Synthetic
Product name(-)-Bicuculline methiodide (mM/ml), GABAA antagonist
DescriptionGABAA antagonist. 1 ml water soluble pack.
Water-soluble GABAA antagonist. Methiodide salt of (+)-bicuculline (ab120107). Actions on neuronal Ca2+-activated K+ channels reported.
Soluble in 1 ml water to give specified mM/ml concentration.
Chemical name[S-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in 1 ml water to give specified mM/ml concentration
This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab144491 has been referenced in 6 publications.
- Glasgow SD & Chapman CA Muscarinic depolarization of layer II neurons of the parasubiculum. PLoS One 8:e58901 (2013). PubMed: 23520542
- Haam J et al. GABA is excitatory in adult vasopressinergic neuroendocrine cells. J Neurosci 32:572-82 (2012). PubMed: 22238092
- Platt NJ et al. Striatal dopamine transmission is subtly modified in human A53Ta-synuclein overexpressing mice. PLoS One 7:e36397 (2012). PubMed: 22570709
- Threlfell S et al. Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons. Neuron 75:58-64 (2012). PubMed: 22794260
- Blum R et al. Neuronal network formation from reprogrammed early postnatal rat cortical glial cells. Cereb Cortex 21:413-24 (2011). PubMed: 20562320
- Jeong HJ et al. N-arachidonyl-glycine modulates synaptic transmission in superficial dorsal horn. Br J Pharmacol 161:925-35 (2010). PubMed: 20860669