Overview

  • Product name

    (-)-Bicuculline methobromide, GABAA antagonist
  • Description

    GABAA antagonist
  • Biological description

    Water-soluble GABAA antagonist. Methobromide salt of (+)-bicuculline (ab120107). Actions on neuronal Ca2+-activated K+ channels reported.

    Also available in simple stock solutions (ab146681) - add 1 ml of water to get an exact, ready-to-use concentration.

  • Purity

    > 98%
  • CAS Number

    73604-30-5
  • Chemical structure

    Chemical Structure

Properties

Associated products

Images

  • Saturation of LTP by nicotine application.

    VSD recordings were performed from the granular layer of cerebellar slices (pre-treated with 10 µM bicuculline methobromide) to measure the spatial organisation of the effect of nicotine following TBS.

    (Panel A) Images of background epifluorescence in stained cerebellar slices show the granular layer (GRL), Purkinje cell layer (PCL), molecular layer (ML), mossy fibre bundle (mf), and position of the stimulating electrode (yellow dots). Coloured optical maps of granular layer activity evoked by a single mossy fibre pulse are compared before and after the induction of long-term synaptic plasticity by TBS.

References

This product has been referenced in:

  • Seutin V & Johnson SW Recent advances in the pharmacology of quaternary salts of bicuculline. Trends Pharmacol Sci 20:268-70 (1999). Read more (PubMed: 10390643) »
  • Olsen RW  et al. Studies on the neuropharmacological activity of bicuculline and related compounds. Brain Res 102:283-99 (1976). Read more (PubMed: 1247886) »
See all 6 Publications for this product

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