(-)-Bicuculline methochloride, GABAA antagonist (ab120110)
Key features and details
- GABAA antagonist
- CAS Number: 53552-05-9
- Purity: > 99%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
(-)-Bicuculline methochloride, GABAA antagonist -
Description
GABAA antagonist -
Biological description
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Purity
> 99% -
CAS Number
53552-05-9 -
Chemical structure
Properties
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Chemical name
[S-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium chloride -
Molecular weight
417.85 -
Molecular formula
C21H20ClNO6 -
PubChem identifier
56972147 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM -
Handling
This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
[Cl-].C[N+]5(C)CCc1cc6OCOc6cc1[C@@H]5[C@H]4OC(=O)c3c4ccc2OCOc23 -
Source
Synthetic
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Research areas
Images
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Chemical Structure - (-)-Bicuculline methochloride, GABAA antagonist (ab120110)2D chemical structure image of ab120110, (-)-Bicuculline methochloride, GABAA antagonist
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Functional Studies - (-)-Bicuculline methochloride, GABAA antagonist (ab120110)Image from Corns LF et al., Neurosci Lett. 2013;553:57-62. Fig 2B.; doi: 10.1016/j.neulet.2013.07.007.Current clamp recordings demonstrating that the depolarisation of ependymal cells in response to GABA (200 μM) is partially antagonised by bicuculline (ab120110, 100 μM) in a reversible manner. -
Functional Studies - (-)-Bicuculline methochloride, GABAA antagonist (ab120110)Image from Corns LF et al., Neurosci Lett. 2013;553:57-62. Fig 2Ai.; doi: 10.1016/j.neulet.2013.07.007. Reproduced under the Creative Commons license https://creativecommons.org/licenses/by/3.0/Group data for responses to GABA alone or in the presence of bicuculline (bic, ab120110) and/or nipecotic acid (NA).
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (13)
ab120110 has been referenced in 13 publications.
- Nagai J et al. Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue. Cell 177:1280-1292.e20 (2019). PubMed: 31031006
- Chiu SL et al. GRASP1 Regulates Synaptic Plasticity and Learning through Endosomal Recycling of AMPA Receptors. Neuron 93:1405-1419.e8 (2017). PubMed: 28285821
- Arama J et al. GABAA receptor activity shapes the formation of inhibitory synapses between developing medium spiny neurons. Front Cell Neurosci 9:290 (2015). PubMed: 26300728
- Li DP et al. mGluR5 Upregulation increases excitability of hypothalamic presympathetic neurons through NMDA receptor trafficking in spontaneously hypertensive rats. J Neurosci 34:4309-17 (2014). PubMed: 24647951
- Di Angelantonio S et al. A role for intracellular zinc in glioma alteration of neuronal chloride equilibrium. Cell Death Dis 5:e1501 (2014). PubMed: 25356870