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  1. Link

    --bicuculline-methochloride-gabaa-antagonist-ab120110.pdf

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Neuroscience Neurotransmitter Amino Acids GABA
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(-)-Bicuculline methochloride, GABAA antagonist (ab120110)

  • Datasheet
  • SDS
Submit a review Q&A (1)References (17)

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Chemical Structure - (-)-Bicuculline methochloride, GABA<sub>A</sub> antagonist (ab120110)
  • Functional Studies - (-)-Bicuculline methochloride, GABA<sub>A</sub> antagonist (ab120110)
  • Functional Studies - (-)-Bicuculline methochloride, GABA<sub>A</sub> antagonist (ab120110)

Key features and details

  • GABAA antagonist
  • CAS Number: 53552-05-9
  • Soluble in water to 100 mM
  • Form / State: Lyophilized
  • Source: Synthetic

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Overview

  • Product name

    (-)-Bicuculline methochloride, GABAA antagonist
  • Description

    GABAA antagonist
  • CAS Number

    53552-05-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [S-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium chloride
  • Molecular weight

    417.85
  • Molecular formula

    C21H20ClNO6
  • PubChem identifier

    56972147
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    [Cl-].C[N+]5(C)CCc1cc6OCOc6cc1[C@@H]5[C@H]4OC(=O)c3c4ccc2OCOc23
  • Source

    Synthetic

  • Research areas

    • Neuroscience
    • Neurotransmitter
    • Amino Acids
    • GABA
    • Biochemicals
    • Product Range
    • Just Add Water
    • Biochemicals
    • Chemical Type
    • Biochemicals
    • Biochemicals
    • Pharmacology
    • Receptors & Transporters
    • GABA
    • GABAA
    • Biochemicals
    • Pharmacology
    • Receptors & Transporters
    • GABA
    • GABAA
    • Antagonists
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • GABA
    • GABAA
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • GABA
    • GABAA
    • Antagonists
    • Biochemicals
    • Research Area
    • Schizophrenia
    • GABA
    • GABAA
    • Biochemicals
    • Research Area
    • Schizophrenia
    • GABA
    • GABAA
    • Antagonists
    • Biochemicals
    • Research Area
    • Stress / Anxiety
    • GABA
    • GABAA
    • Biochemicals
    • Research Area
    • Stress / Anxiety
    • GABA
    • GABAA
    • Antagonists

Images

  • Chemical Structure - (-)-Bicuculline methochloride, GABA<sub>A</sub> antagonist (ab120110)
    Chemical Structure - (-)-Bicuculline methochloride, GABAA antagonist (ab120110)
    2D chemical structure image of ab120110, (-)-Bicuculline methochloride, GABAA antagonist
  • Functional Studies - (-)-Bicuculline methochloride, GABA<sub>A</sub> antagonist (ab120110)
    Functional Studies - (-)-Bicuculline methochloride, GABAA antagonist (ab120110)Image from Corns LF et al., Neurosci Lett. 2013;553:57-62. Fig 2B.; doi: 10.1016/j.neulet.2013.07.007.
    Current clamp recordings demonstrating that the depolarisation of ependymal cells in response to GABA (200 μM) is partially antagonised by bicuculline (ab120110, 100 μM) in a reversible manner.
  • Functional Studies - (-)-Bicuculline methochloride, GABA<sub>A</sub> antagonist (ab120110)
    Functional Studies - (-)-Bicuculline methochloride, GABAA antagonist (ab120110)Image from Corns LF et al., Neurosci Lett. 2013;553:57-62. Fig 2Ai.; doi: 10.1016/j.neulet.2013.07.007. Reproduced under the Creative Commons license https://creativecommons.org/licenses/by/3.0/
    Group data for responses to GABA alone or in the presence of bicuculline (bic, ab120110) and/or nipecotic acid (NA).

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download

References (17)

Publishing research using ab120110? Please let us know so that we can cite the reference in this datasheet.

ab120110 has been referenced in 17 publications.

  • Wu K  et al. Activity- and sleep-dependent regulation of tonic inhibition by Shisa7. Cell Rep 34:108899 (2021). PubMed: 33761345
  • Iacobucci S  et al. The histone demethylase PHF8 regulates astrocyte differentiation and function. Development 148:N/A (2021). PubMed: 34081130
  • Sun ZM  et al. [Chronic phosphoproteomic in temporal lobe epilepsy mouse models induced by kainic acid]. Beijing Da Xue Xue Bao Yi Xue Ban 51:197-205 (2019). PubMed: 30996354
  • Kikuchi K  et al. Involvement of SRF coactivator MKL2 in BDNF-mediated activation of the synaptic activity-responsive element in the Arc gene. J Neurochem 148:204-218 (2019). PubMed: 30244496
  • Nagai J  et al. Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue. Cell 177:1280-1292.e20 (2019). PubMed: 31031006
View all Publications for this product

Customer reviews and Q&As

Show All Reviews Q&A
Submit a review Submit a question

Question

I would like to know the PKa value of Bicuculline methochloride!

Read More

Abcam community

Verified customer

Asked on Oct 02 2012

Answer

Thank you for contacting Abcam.

Unfortunately we don’t have a pKa value listed for this compound. I have done a quick literature search and nothing seems to be coming up.

Usually if we have any such figures (IC50, Kd, pKa) we would list them on the datasheet.

Sorry we can’t be more help, but please let us know if you have any further questions in the future

Read More

Abcam Scientific Support

Answered on Oct 02 2012

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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