Name: (-)-Bicuculline methochloride, GABA<sub>A</sub> antagonist
SKU: ab120110

Datasheet
References (9)

Product name

(-)-Bicuculline methochloride, GABA_A antagonist
Description

GABA_A antagonist
Biological description

Water-soluble GABA_A antagonist. Methochloride salt of (+)-bicuculline (ab120107). Actions on neuronal Ca²⁺-activated K⁺ channels reported.

Also available in simple stock solutions (ab146682) - add 1 ml of water to get an exact, ready-to-use concentration.
Purity

> 99%
CAS Number

53552-05-9
Chemical structure

Chemical name

[S-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium chloride
Molecular weight

417.85
Molecular formula

C₂₁H₂₀ClNO₆
PubChem identifier

56972147
Storage instructions

Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overview

Soluble in water to 100 mM
Handling

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
SMILES

[Cl-].C[N+]5(C)CCc1cc6OCOc6cc1[C@@H]5[C@H]4OC(=O)c3c4ccc2OCOc23
Source

Synthetic
Research areas

Related Products

Functional Studies - (-)-Bicuculline methochloride, GABA_A antagonist (ab120110)Image from Corns LF et al., Neurosci Lett. 2013;553:57-62. Fig 2B.; doi: 10.1016/j.neulet.2013.07.007.

Current clamp recordings demonstrating that the depolarisation of ependymal cells in response to GABA (200 μM) is partially antagonised by bicuculline (ab120110, 100 μM) in a reversible manner.
Functional Studies - (-)-Bicuculline methochloride, GABA_A antagonist (ab120110)Image from Corns LF et al., Neurosci Lett. 2013;553:57-62. Fig 2Ai.; doi: 10.1016/j.neulet.2013.07.007.

Group data for responses to GABA alone or in the presence of bicuculline (bic, ab120110) and/or nipecotic acid (NA).

This product has been referenced in:

Seutin V & Johnson SW Recent advances in the pharmacology of quaternary salts of bicuculline. Trends Pharmacol Sci 20:268-70 (1999). Read more (PubMed: 10390643) »
Olsen RW et al. Studies on the neuropharmacological activity of bicuculline and related compounds. Brain Res 102:283-99 (1976). Read more (PubMed: 1247886) »

See all 9 Publications for this product

Publishing research using ab120110? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

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Question

I would like to know the PKa value of Bicuculline methochloride!

Abcam community

Verified customer

Asked on Oct 02 2012

Answer

Thank you for contacting Abcam.

Unfortunately we don’t have a pKa value listed for this compound. I have done a quick literature search and nothing seems to be coming up.

Usually if we have any such figures (IC50, Kd, pKa) we would list them on the datasheet.

Sorry we can’t be more help, but please let us know if you have any further questions in the future

Abcam Scientific Support

Answered on Oct 02 2012

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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(-)-Bicuculline methochloride, GABA_A antagonist (ab120110)

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