Overview

  • Product name
    (-)-Bicuculline methochloride, GABAA antagonist
  • Description
    GABAA antagonist
  • Biological description
    Water-soluble GABAA antagonist. Methochloride salt of (+)-bicuculline (ab120107). Actions on neuronal Ca2+-activated K+ channels reported.

    Also available in simple stock solutions (ab146682) - add 1 ml of water to get an exact, ready-to-use concentration.
  • Purity
    > 99%
  • CAS Number
    53552-05-9
  • Chemical structure
    Chemical Structure

Properties

Images

  • Current clamp recordings demonstrating that the depolarisation of ependymal cells in response to GABA (200 μM) is partially antagonised by bicuculline (ab120110, 100 μM) in a reversible manner.
  • Group data for responses to GABA alone or in the presence of bicuculline (bic, ab120110) and/or nipecotic acid (NA).

References

This product has been referenced in:
  • Seutin V & Johnson SW Recent advances in the pharmacology of quaternary salts of bicuculline. Trends Pharmacol Sci 20:268-70 (1999). Read more (PubMed: 10390643) »
  • Olsen RW  et al. Studies on the neuropharmacological activity of bicuculline and related compounds. Brain Res 102:283-99 (1976). Read more (PubMed: 1247886) »
See all 9 Publications for this product

Customer reviews and Q&As

Question
Answer

Thank you for contacting Abcam.

Unfortunately we don’t have a pKa value listed for this compound. I have done a quick literature search and nothing seems to be coming up.

Usually if we have any such figures (IC50, Kd, pKa) we would list them on the datasheet.

Sorry we can’t be more help, but please let us know if you have any further questions in the future

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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