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  1. Link

    --cannabidiol-natural-cannabinoid-ab120448.pdf

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Neuroscience Neurotransmission Receptors / Channels GPCR Cannabinoid Receptor
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(-)-Cannabidiol, Natural cannabinoid (ab120448)

  • Datasheet
  • SDS
  • COA
Submit a review Q&A (1)

Product price, shipping and contact information

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Chemical Structure - (-)-Cannabidiol, Natural cannabinoid (ab120448)
  • Functional Studies - (-)-Cannabidiol, Natural cannabinoid (ab120448)

Key features and details

  • Common constituent of Cannabis
  • CAS Number: 13956-29-1
  • Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Form / State: Solid
  • Source: Synthetic

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Overview

  • Product name

    (-)-Cannabidiol, Natural cannabinoid
  • Description

    Common constituent of Cannabis
  • Alternative names

    • CBD
  • Biological description

    Common constituent of Cannabis with much lower affinity at CB1 and CB2 receptors (Ki values are 4350 and 2860 nM, respectively) than Delta-9 THC. Elicits anticonvulsant, anticancer, anti-inflammatory and neuroprotective effects. Protects retinal neurons in diabetic models.

  • CAS Number

    13956-29-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol
  • Molecular weight

    314.47
  • Molecular formula

    C21H30O2
  • PubChem identifier

    644019
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=C)[C@@H]2CCC(C)=C[C@H]2c1c(O)cc(CCCCC)cc1O
  • Source

    Synthetic

  • Research areas

    • Neuroscience
    • Neurotransmission
    • Receptors / Channels
    • GPCR
    • Cannabinoid Receptor
    • Cardiovascular
    • Lipids / Lipoproteins
    • Lipid Metabolism
    • Cholesterol Metabolism
    • Cardiovascular
    • Atherosclerosis
    • Lipoprotein metabolism
    • Biochemicals
    • Chemical Type
    • Biochemicals
    • Biochemicals
    • Pharmacology
    • Receptors & Transporters
    • Cannabinoid
    • Non-selective
    • Biochemicals
    • Pharmacology
    • Receptors & Transporters
    • Cannabinoid
    • Non-selective
    • Agonists
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Lipid and lipoprotein metabolism
    • Cholesterol Metabolism
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Lipid and lipoprotein metabolism
    • Lipoprotein metabolism
    • Metabolism
    • Types of disease
    • Heart disease
    • Biochemicals
    • Research Area
    • Addiction
    • Cannabinoid
    • Non-selective
    • Biochemicals
    • Research Area
    • Addiction
    • Cannabinoid
    • Non-selective
    • Agonists
    • Biochemicals
    • Research Area
    • Obesity
    • Cannabinoid
    • Non-selective
    • Biochemicals
    • Research Area
    • Obesity
    • Cannabinoid
    • Non-selective
    • Agonists
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • Cannabinoid
    • Non-selective
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • Cannabinoid
    • Non-selective
    • Agonists
    • Biochemicals
    • Pharmacology
    • Signaling
    • Immunomodulators
    • Immunomodulators & Immunosuppressants
    • Biochemicals
    • Chemical Type
    • Controlled substances

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab120448 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies
Use at an assay dependent concentration.
Notes
Functional Studies
Use at an assay dependent concentration.

Images

  • Chemical Structure - (-)-Cannabidiol, Natural cannabinoid (ab120448)
    Chemical Structure - (-)-Cannabidiol, Natural cannabinoid (ab120448)
    2D chemical structure image of ab120448, (-)-Cannabidiol, Natural cannabinoid
  • Functional Studies - (-)-Cannabidiol, Natural cannabinoid (ab120448)
    Functional Studies - (-)-Cannabidiol, Natural cannabinoid (ab120448)
    ab109225 staining Nox4 in HeLa cells treated with (-)-cannabidiol (ab120448), by ICC/IF. Increase in Nox4 expression correlates with increased concentration of (-)-cannabidiol, as described in literature.
    The cells were incubated at 37°C for 6h in media containing different concentrations of ab120847 ((-)-cannabidiol) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab109225 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download
  • COA

References (0)

Publishing research using ab120448? Please let us know so that we can cite the reference in this datasheet.

ab120448 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Question

Thanks for your quick reply,
I need some further information I couldn't find in the site (one of the problem i'm having with my pathology is i can hardly see the pc monitor)

Can you please tell me if the productCannabidiol (product code: ab120448; formerly Asc-448) can be purchased from Italy and if I need to get a medical prescription in order to buy it.

Under which form is this product available? Pills or vials?

Thank you for your attention. Best regards.

Read More

Abcam community

Verified customer

Asked on Oct 08 2012

Answer

Thank you for contacting us.

Please note that these products are "for research use only and are not intended for diagnostic or therapeutic use". I would suggest you to contact your doctor for any advice on health condition you have.

I hope this information is nevertheless helpful to you. Please do not hesitate to contact us if you need any more advice or information.

Use our products? Submit an Abreview. Earn rewards!
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Read More

Abcam Scientific Support

Answered on Oct 08 2012

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

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