Overview

  • Product name

    (-)-Indolactam V,  PKC activator
  • Description

    Potent PKC activator
  • Biological description

    Potent PKC activator (Ki values are 11, 6, 19, 8, 22, and 16 nM for α, β, γ, δ, ε, and η isozymes respectively). Induces pancreatic progenitor differentiation in embryonic stem cells. Shows tumorgenic effects in vivo.
  • Purity

    > 97%
  • CAS Number

    90365-57-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2S,5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)- 3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one
  • Molecular weight

    301.38
  • Molecular formula

    C17H23N3O2
  • PubChem identifier

    105000
  • Storage instructions

    Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark.
  • Solubility overview

    Soluble in ethanol and in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)[C@H]1C(=O)N[C@@H](CC2=CNC3=C2C(=CC=C3)N1C)CO
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Bronner SM  et al. Overturning indolyne regioselectivities and synthesis of indolactam V. J Am Chem Soc 133:3832-5 (2011). Read more (PubMed: 21351773) »
  • Grabauskas G  et al. Protein kinase signalling requirements for metabotropic action of kainate receptors in rat CA1 pyramidal neurones. J Physiol 579:363-73 (2007). Read more (PubMed: 17158174) »
  • Heikkilä J & Akerman KE (-)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor functions in SH-SY5Y human neuroblastoma cells. Biochem Biophys Res Commun 162:1207-13 (1989). Read more (PubMed: 2764930) »

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