(-)-Schisandrin B, anti-inflammatory and antioxidant agent (ab143549)

Overview

  • Product name

    (-)-Schisandrin B, anti-inflammatory and antioxidant agent
  • Description

    Anti-inflammatory and antioxidant agent
  • Biological description

    Anti-inflammatory and antioxidant agent. Inhibits ROS production in microglia. Modulates NFκB and Nrf2. Modulates proliferation and phosphorylation of c-Raf, MEK, ERK, JNK, and p38. Shows hepatoprotective and cardioprotective effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    61281-37-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1,2,3,13-tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydrobenzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxole
  • Molecular weight

    400.47
  • Molecular formula

    C23H28O6
  • PubChem identifier

    108130
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1CC2=CC3=C(C(=C2C4=C(C(=C(C=C4CC1C)OC)OC)OC)OC)OCO3
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Chen P  et al. Beneficial effects of schisandrin B on the cardiac function in mice model of myocardial infarction. PLoS One 8:e79418 (2013). Read more (PubMed: 24260217) »
  • Zeng KW  et al. Schisandrin B exerts anti-neuroinflammatory activity by inhibiting the Toll-like receptor 4-dependent MyD88/IKK/NF-?B signaling pathway in lipopolysaccharide-induced microglia. Eur J Pharmacol 692:29-37 (2012). Read more (PubMed: 22698579) »
  • Checker R  et al. Schisandrin B exhibits anti-inflammatory activity through modulation of the redox-sensitive transcription factors Nrf2 and NF-?B. Free Radic Biol Med 53:1421-30 (2012). Read more (PubMed: 22917978) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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