(-)-Warfarin (S-Warfarin), Vitamin K1-epoxide reductase inhibitor (ab143733)

Overview

  • Product name

    (-)-Warfarin (S-Warfarin), Vitamin K1-epoxide reductase inhibitor
  • Description

    Optically active S-Warfarin enantiomer. Vitamin K1-epoxide reductase inhibitor.
  • Alternative names

    • S-Warfarin
  • Biological description

    Optically active S-Warfarin (ab141979) enantiomer. Vitamin K1-epoxide reductase inhibitor. CYP2C9 substrate. Inhibits vitamin K-dependent synthesis of clotting factors. Shows 2.5 times more potent anticoagulant effects (IC50 = 0.21 μM) than R-Warfarin (ab143734) in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    5543-57-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Kamiyama E  et al. Inhibitory effects of angiotensin receptor blockers on CYP2C9 activity in human liver microsomes. Drug Metab Pharmacokinet 22:267-75 (2007). Read more (PubMed: 17827781) »
  • Mosterd JJ & Thijssen HH The relationship between the vitamin K cycle inhibition and the plasma anticoagulant response at steady-state S-warfarin conditions in the rat. J Pharmacol Exp Ther 260:1081-5 (1992). Read more (PubMed: 1545379) »
  • Yacobi A  et al. Comparative pharmacokinetics of coumarin anticoagulants. XLVI: Effect of treatment of phenobarbital on pharmacokinetics of (S)-(-)-warfarin in rats. J Pharm Sci 69:634-6 (1980). Read more (PubMed: 7205571) »

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