(-)-Warfarin sodium salt, Vitamin K1-epoxide reductase inhibitor (ab143735)

Overview

  • Product name

    (-)-Warfarin sodium salt, Vitamin K1-epoxide reductase inhibitor
  • Description

    Optically active S enantiomer of Warfarin Sodium. Vitamin K1-epoxide reductase inhibitor.
  • Biological description

    Optically active S enantiomer of Warfarin Sodium (ab142969). Vitamin K1-epoxide reductase inhibitor. CYP2C9 substrate. Inhibits vitamin K-dependent synthesis of clotting factors. Shows anticoagulant effects in vivo. Orally active.
  • Purity

    > 98%
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Winkler EA  et al. Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice. Proc Natl Acad Sci U S A 111:E1035-42 (2014). Read more (PubMed: 24591593) »
  • Maddison J  et al. The pharmacokinetics and pharmacodynamics of single dose (R)- and (S)-warfarin administered separately and together: relationship to VKORC1 genotype. Br J Clin Pharmacol 75:208-16 (2013). Read more (PubMed: 22616655) »
  • Côté N  et al. Inhibition of ectonucleotidase with ARL67156 prevents the development of calcific aortic valve disease in warfarin-treated rats. Eur J Pharmacol 689:139-46 (2012). Read more (PubMed: 22659116) »

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