(+)-5-trans-Cloprostenol, prostaglandin F2alpha derivative (ab144420)

Overview

  • Product name

    (+)-5-trans-Cloprostenol, prostaglandin F2alpha derivative
  • Description

    Synthetic prostaglandin F derivative
  • Alternative names

    • (+)-5,6-trans Cloprostenol
    • D-Cloprostenol
  • Biological description

    Synthetic prostaglandin Fderivative. Minor impurity produced in the synthesis of (+)-cloprostenol. Luteolytic agent for the induction of estrus in animal models. The (+)-5-trans isomer is less active than the 5-cis form in terminating pregnancy in the hamster

  • Purity

    > 98%
  • CAS Number

    57968-81-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (+)-16-(3-Chlorophenoxy)-9α,11α,15R-trihydroxy-17,18,19,20-tetranorprosta-5E,13E-dien-1-oic acid
  • Molecular weight

    424.90
  • Molecular formula

    C22H29ClO6
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Valldecabres-Torres X  et al. Effects of d-cloprostenol dose and corpus luteum age on ovulation, luteal function, and morphology in nonlactating dairy cows with early corpora lutea. J Dairy Sci 95:4389-95 (2012). Read more (PubMed: 22818452) »
  • Beretta C & Cavalli M A sheer pharmacologic approach to compare the contractile effects of PGF2alpha, DL-cloprostenol and D-cloprostenol on isolated uterine, tracheal, ileal and arterial smooth muscle preparations. Theriogenology 62:837-46 (2004). Read more (PubMed: 15251235) »
  • Bowler J  et al. Double bond isomers of cloprostenol. Prostaglandins 17:789-800 (1979). Read more (PubMed: 504688) »

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