Key features and details
- GABAA antagonist
- CAS Number: 485-49-4
- Purity: > 98%
- Soluble in ethanol to 5 mM and DMSO to 100 mM (with heating)
- Form / State: Solid
- Source: Synthetic
Product name(+)-Bicuculline, GABAA antagonist
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in ethanol to 5 mM and DMSO to 100 mM (with heating)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120107 has been referenced in 30 publications.
- Malik AR et al. SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology. Cell Rep 26:2792-2804.e6 (2019). PubMed: 30840898
- Ren L et al. Anesthetics alleviate learning and memory impairment induced by electroconvulsive shock by regulation of NMDA receptor-mediated metaplasticity in depressive rats. Neurobiol Learn Mem 155:65-77 (2018). PubMed: 29953948
- Zonouzi M et al. GABAergic regulation of cerebellar NG2 cell development is altered in perinatal white matter injury. Nat Neurosci 18:674-82 (2015). PubMed: 25821912
- Martinello K et al. Cholinergic afferent stimulation induces axonal function plasticity in adult hippocampal granule cells. Neuron 85:346-63 (2015). PubMed: 25578363
- Vecchia D et al. Mechanism underlying unaltered cortical inhibitory synaptic transmission in contrast with enhanced excitatory transmission in CaV2.1 knockin migraine mice. Neurobiol Dis 69:225-34 (2014). PubMed: 24907493