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    -jq1-bet-bromodomain-inhibitor-ab141498.pdf

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Epigenetics and Nuclear Signaling Chromatin Modifying Enzymes Ubiquitylation
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(+)-JQ1, BET bromodomain inhibitor (ab141498)

  • Datasheet
  • SDS
  • COA
Submit a review Q&A (1)References (3)

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Key features and details

  • Potent, selective and cell-permeable BET bromodomain inhibitor
  • CAS Number: 1268524-70-4
  • Purity: > 99%
  • Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Form / State: Solid
  • Source: Synthetic

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Overview

  • Product name

    (+)-JQ1, BET bromodomain inhibitor
  • Description

    Potent, selective and cell-permeable BET bromodomain inhibitor
  • Alternative names

    • (S)-(+)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
    • 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6S)-
  • Purity

    > 99%
  • CAS Number

    1268524-70-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid tert-butyl ester
  • Molecular weight

    456.99
  • Molecular formula

    C23H25ClN4O2S
  • PubChem identifier

    46907787
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C
  • Source

    Synthetic

  • Research areas

    • Epigenetics and Nuclear Signaling
    • Chromatin Modifying Enzymes
    • Ubiquitylation
    • Epigenetics and Nuclear Signaling
    • Chromatin Binding Proteins
    • Acetyl Lysine
    • Cell Biology
    • Proteolysis / Ubiquitin
    • Proteasome / Ubiquitin
    • Ubiquitin E3 Enzymes
    • RING Finger E3 Ligase
    • Signal Transduction
    • Protein Phosphorylation
    • Ser / Thr Kinases
    • Other Kinases
    • Epigenetics and Nuclear Signaling
    • Transcription
    • Other factors
    • Epigenetics and Nuclear Signaling
    • Transcription
    • Domain Families
    • Developmental Families
    • Other
    • Cancer
    • Oncoproteins/suppressors
    • Tumor suppressors
    • Other
    • Epigenetics and Nuclear Signaling
    • Transcription
    • Bromodomain containing
    • Biochemicals
    • Chemical Type
    • Biochemicals
    • Biochemicals
    • Pharmacology
    • Signaling
    • Epigenetics
    • Other
    • Biochemicals
    • Research Area
    • Cancer
    • Epigenetics
    • Other
    • Biochemicals
    • Research Area
    • Epigenetics
    • Other

Associated products

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download
    • COA

    References (3)

    Publishing research using ab141498? Please let us know so that we can cite the reference in this datasheet.

    ab141498 has been referenced in 3 publications.

    • Yamamoto T  et al. BRD4 promotes metastatic potential in oral squamous cell carcinoma through the epigenetic regulation of the MMP2 gene. Br J Cancer N/A:N/A (2020). PubMed: 32499570
    • Kim E  et al. Angelica gigas Nakai and Decursin Downregulate Myc Expression to Promote Cell Death in B-cell Lymphoma. Sci Rep 8:10590 (2018). PubMed: 30002430
    • Kramer M  et al. Proliferation and Survival of Embryonic Sympathetic Neuroblasts by MYCN and Activated ALK Signaling. J Neurosci 36:10425-10439 (2016). PubMed: 27707976

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    Question

    Estoy interesada en el producto JQ1, tanto en enantiomero positivo como el negativo para usarlo como control.
    El producto que teneis cuya referencia es: (+)-JQ1 (ab141498) hace referencia solo al enantiomero positivo o vienen los dos enantiomeros?

    Read More

    Abcam community

    Verified customer

    Asked on Dec 11 2013

    Answer


    Te confirmo que el producto ab141498 solo se suministra como enantiómero positivo, que es el enantiómero activo que actúa como potente inhibidor de BET. Podría consultar con el laboratorio si fuera posible aislar el isómero negativo, o la mezcla racemica en caso de interesaros.

    Read More

    Ariana Veiga

    Abcam Scientific Support

    Answered on Dec 11 2013

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
    For licensing inquiries, please contact partnerships@abcam.com

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