(+)-JQ1, BET bromodomain inhibitor (ab141498)
- Datasheet
- References (2)
Overview
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Product name
(+)-JQ1, BET bromodomain inhibitor -
Description
Potent, selective and cell-permeable BET bromodomain inhibitor -
Alternative names
- (S)-(+)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
- 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6S)-
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Biological description
Potent, selective and cell-permeable BET bromodomain inhibitor (Kd values are 50 and 90 nM at BRD4 first and second bromodomains, respectively).
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Purity
> 99% -
CAS Number
1268524-70-4 -
Chemical structure
Properties
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Chemical name
(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid tert-butyl ester -
Molecular weight
456.99 -
Molecular formula
C23H25ClN4O2S -
PubChem identifier
46907787 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C -
Source
Synthetic
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Research areas
References
This product has been referenced in:
- Li Z et al. The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation. Nucleic Acids Res 41:277-87 (2013). Read more (PubMed: 23087374) »
- Matzuk MM et al. Small-molecule inhibition of BRDT for male contraception. Cell 150:673-84 (2012). Read more (PubMed: 22901802) »
- Filippakopoulos P et al. Selective inhibition of BET bromodomains. Nature 468:1067-73 (2010). Read more (PubMed: 20871596) »
