(+)-MK 801 maleate (Dizocilpine) (mM/ml), NMDA antagonist (ab144485)

Submit a review Q&A (1)References (17)

Overview

  • Product name

    (+)-MK 801 maleate (Dizocilpine) (mM/ml), NMDA antagonist

  • Description

    Non-competitive NMDA antagonist. 1 ml water soluble pack.

  • Alternative names

    • Dizocilpine

  • Biological description

    Potent, selective non-competitive NMDA receptor antagonist. Open channel blocker of the NMDA receptor operated ion channel.

    Soluble in 1 ml water to give specified mM/ml concentration. Find out more.

  • Purity

    > 99%

  • CAS Number

    77086-22-7

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate

  • Molecular weight

    337.37

  • Molecular formula

    C16H15N.C4H4O4

  • PubChem identifier

    6420042

  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.

  • Solubility overview

    Soluble in 1 ml water to give specified mM/ml concentration

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C(O)/C=CC(=O)O.C[C@@]42N[C@H](Cc1ccccc12)c3ccccc34

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Hatfield RH  et al. The dose-response relationship and therapeutic window for dizocilpine (MK-801) in a rat focal ischaemia model. Eur J Pharmacol 216:1-7 (1992). Read more (PubMed: 1526248) »
  • Woodruff GN  et al. The interaction between MK-801 and receptors for N-methyl-D-aspartate: functional consequences. Neuropharmacology 26:903-9 (1987). Read more (PubMed: 2821432) »
  • Wong EH  et al. The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist. Proc Natl Acad Sci U S A 83:7104-8 (1986). Read more (PubMed: 3529096) »
See all 17 Publications for this product

Publishing research using ab144485? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

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Question

lot APN12070-12-3
amount per vial?
conc?

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Answer


This product is supplied as a solid. The amount of the compound in the vial is 3.37mg.
If one uses only 1ml of water, then a concentration of 10mM is obtained.
The addition of 1ml of water to get 10mM solution gives a solubility of 10mM/ml for this product.
I will work on updating the datasheet as this information should be on the datasheet to avoid confusion and gives the customer more accurate information.

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