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Potent p53-MDM2 binding inhibitor
Potent p53-MDM2 binding inhibitor (IC
50 = 90 nM). Enantiomer of (+)-Nutlin-3 ( ab144426). Shows antiproliferative effects (IC 50 values are 2.2 and 1.3 µM for human skin and murine fibroblasts respectively). Shows antitumor effects in vivo. Orally active.
30H 30Cl 2N 4O 4
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in DMSO
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our
frequently asked questions (FAQ) page for more details.
This product has been referenced in:
et al. Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia. Mol Cancer 13:116 (2014).
Read more (PubMed: 24885082) »
et al. Immune escape phenomenon in molluscum contagiosum and the induction of apoptosis. J Dermatol 41:1058-64 (2014).
Read more (PubMed: 25438641) »
et al. The p53 transcriptional pathway is preserved in ATMmutated and NOTCH1mutated chronic lymphocytic leukemias. Oncotarget 5:12635-45 (2014).
Read more (PubMed: 25587027) »
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"