Overview

  • Product name

    (+)-Nutlin-3, p53-MDM2 binding inhibitor
  • Description

    p53-MDM2 binding inhibitor
  • Biological description

    p53-MDM2 binding inhibitor (IC50 = 13 μM). Less potent enantiomer of (-)-Nutlin-3 (Asc-4428). Shows antiproliferative effects (IC50 values are 2.2 and 1.3 µM for human skin and murine fibroblasts respectively). Shows antitumor effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    548472-68-0
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Zhang X  et al. Targeting of mutant p53-induced FoxM1 with thiostrepton induces cytotoxicity and enhances carboplatin sensitivity in cancer cells. Oncotarget 5:11365-80 (2014). Read more (PubMed: 25426548) »
  • Yamauchi-Yamada A  et al. Immune escape phenomenon in molluscum contagiosum and the induction of apoptosis. J Dermatol 41:1058-64 (2014). Read more (PubMed: 25438641) »
  • Shi XL  et al. Nutlin-3-induced redistribution of chromatin-bound IFI16 in human hepatocellular carcinoma cells in vitro is associated with p53 activation. Acta Pharmacol Sin : (2014). Read more (PubMed: 25544361) »

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