Key features and details
- p53-MDM2 binding inhibitor
- CAS Number: 548472-68-0
- Purity: > 98%
- Soluble in DMSO
- Form / State: Solid
- Source: Synthetic
Product name(+)-Nutlin-3, p53-MDM2 binding inhibitor
Descriptionp53-MDM2 binding inhibitor
Biological descriptionp53-MDM2 binding inhibitor (IC50 = 13 μM). Less potent enantiomer of (-)-Nutlin-3 (Asc-4428). Shows antiproliferative effects (IC50 values are 2.2 and 1.3 µM for human skin and murine fibroblasts respectively). Shows antitumor effects in vivo. Orally active.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Receptors & Transporters
- Group I & II
- Allosteric modulators
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab144426 has not yet been referenced specifically in any publications.