1-EBIO, Activator of Ca2+-activated K+ channels and CFTR channels (ab120258)
Key features and details
- Activator of Ca2+-activated K+ channels and CFTR channels
- CAS Number: 10045-45-1
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
1-EBIO, Activator of Ca2+-activated K+ channels and CFTR channels -
Description
Activator of Ca2+-activated K+ channels and CFTR channels -
Alternative names
- IK channel
- SK channel
-
Biological description
Activator of small and intermediate conductance Ca2+ activated K+ channels (SK). Also activates apical membrane Cl- conductance CFTR channel.
-
CAS Number
10045-45-1 -
Chemical structure
Properties
-
Chemical name
1-Ethyl-1,3-dihydro-2H-benzimidazol-2-one -
Molecular weight
162.19 -
Molecular formula
C9H10N2O -
PubChem identifier
82320 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
O=C2Nc1ccccc1N2CC -
Source
Synthetic
-
Research areas
Images
-
Chemical Structure - 1-EBIO, Activator of Ca2+-activated K+ channels and CFTR channels (ab120258)2D chemical structure image of ab120258, 1-EBIO, Activator of Ca2+-activated K+ channels and CFTR channels
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (2)
ab120258 has been referenced in 2 publications.
- Tonini R et al. Small-conductance Ca2+-activated K+ channels modulate action potential-induced Ca2+ transients in hippocampal neurons. J Neurophysiol 109:1514-24 (2013). PubMed: 23255726
- Atchley D et al. Pharmacological enhancement of calcium-activated potassium channel function reduces the effects of repeated stress on fear memory. Behav Brain Res 232:37-43 (2012). PubMed: 22487247