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    1-ebio-activator-of-ca2-activated-k-channels-and-cftr-channels-ab120258.pdf

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Neuroscience Neurotransmission Receptors / Channels Potassium Channels
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1-EBIO, Activator of Ca2+-activated K+ channels and CFTR channels (ab120258)

  • Datasheet
  • SDS
  • COA
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Chemical Structure - 1-EBIO, Activator of Ca<sup>2+</sup>-activated K<sup>+</sup> channels and CFTR channels (ab120258)

    Key features and details

    • Activator of Ca2+-activated K+ channels and CFTR channels
    • CAS Number: 10045-45-1
    • Soluble in DMSO to 100 mM and in ethanol to 100 mM
    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      1-EBIO, Activator of Ca2+-activated K+ channels and CFTR channels
    • Description

      Activator of Ca2+-activated K+ channels and CFTR channels
    • Alternative names

      • IK channel
      • SK channel
    • Biological description

      Activator of small and intermediate conductance Ca2+ activated K+ channels (SK). Also activates apical membrane Cl- conductance CFTR channel.

    • CAS Number

      10045-45-1
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      1-Ethyl-1,3-dihydro-2H-benzimidazol-2-one
    • Molecular weight

      162.19
    • Molecular formula

      C9H10N2O
    • PubChem identifier

      82320
    • Storage instructions

      Store at Room Temperature. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in DMSO to 100 mM and in ethanol to 100 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      O=C2Nc1ccccc1N2CC
    • Source

      Synthetic

    • Research areas

      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • Potassium Channels
      • Neuroscience
      • Neurology process
      • Neural Signal Transduction
      • Cell Biology
      • Other Antibodies
      • Other Antibodies
      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
      • Pharmacology
      • Ion Channels
      • Potassium
      • Activators
      • Biochemicals
      • Pharmacology
      • Ion Channels
      • Chloride
      • Activators
      • Biochemicals
      • Research Area
      • Diabetes
      • Potassium
      • Activators
      • Biochemicals
      • Research Area
      • Heart disease
      • Potassium
      • Activators
      • Biochemicals
      • Research Area
      • Hypertension
      • Potassium
      • Activators
      • Biochemicals
      • Research Area
      • Obesity
      • Potassium
      • Activators
      • Biochemicals
      • Research Area
      • Pain & inflammation
      • Potassium
      • Activators
      • Biochemicals
      • Research Area
      • Respiratory disease
      • Potassium
      • Activators
      • Biochemicals
      • Research Area
      • Stroke
      • Potassium
      • Activators

    Images

    • Chemical Structure - 1-EBIO, Activator of Ca<sup>2+</sup>-activated K<sup>+</sup> channels and CFTR channels (ab120258)
      Chemical Structure - 1-EBIO, Activator of Ca2+-activated K+ channels and CFTR channels (ab120258)
      2D chemical structure image of ab120258, 1-EBIO, Activator of Ca2+-activated K+ channels and CFTR channels

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download
    • COA

    References (2)

    Publishing research using ab120258? Please let us know so that we can cite the reference in this datasheet.

    ab120258 has been referenced in 2 publications.

    • Tonini R  et al. Small-conductance Ca2+-activated K+ channels modulate action potential-induced Ca2+ transients in hippocampal neurons. J Neurophysiol 109:1514-24 (2013). PubMed: 23255726
    • Atchley D  et al. Pharmacological enhancement of calcium-activated potassium channel function reduces the effects of repeated stress on fear memory. Behav Brain Res 232:37-43 (2012). PubMed: 22487247

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