Overview

  • Product name

    1-Naphthyl PP1, PKD inhibitor
  • Description

    ATP-competitive PKD inhibitor. Antiproliferative agent.
  • Biological description

    ATP-competitive PKD inhibitor. Antiproliferative agent. Inhibits tumor cell invasion and induces G2/M arrest. ATP and PP1 analog.
  • Purity

    > 99%
  • CAS Number

    221243-82-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
  • Molecular weight

    317.39
  • Molecular formula

    C19H19N5
  • PubChem identifier

    4877
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)(C)N1C2=C(C(=N1)C3=CC=CC4=CC=CC=C43)C(=NC=N2)N
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Reboutier D  et al. Aurora A is involved in central spindle assembly through phosphorylation of Ser 19 in P150Glued. J Cell Biol 201:65-79 (2013). Read more (PubMed: 23547029) »
  • Tandon M  et al. New pyrazolopyrimidine inhibitors of protein kinase d as potent anticancer agents for prostate cancer cells. PLoS One 8:e75601 (2013). Read more (PubMed: 24086585) »
  • Endo S  et al. A single amino-acid change in ERK1/2 makes the enzyme susceptible to PP1 derivatives. Biochem Biophys Res Commun 341:261-5 (2006). Read more (PubMed: 16431218) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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