Overview

  • Product name

    10-Deacetyltaxol, Antineoplastic agent
  • Description

    Antineoplastic agent
  • Biological description

    Antineoplastic agent. Bioactive precursor of microtubule depolymerization inhibitor Paclitaxel (ab120143). More potent cytotoxic effects against glial and neuroblastoma cell lines than cephalomannine (ab142589). Shows antitumor effects in vivo.
  • Purity

    > 98%
  • CAS Number

    78432-77-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    10-Deacetyltaxol
  • Molecular weight

    811.87
  • Molecular formula

    C45H49NO13
  • PubChem identifier

    155831
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6= CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Helson L Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines. Int J Oncol 2:297-9 (1993). Read more (PubMed: 21573554) »
  • McLaughlin JL  et al. 19-Hydroxybaccatin III, 10-deacetylcephalomannine, and 10-deacetyltaxol: new antitumor taxanes from Taxus wallichiana. J Nat Prod 44:312-9 (0). Read more (PubMed: 7264680) »
  • Guéritte-Voegelein F  et al. [Chemical and biological studies on Taxol (Paclitaxel) and Taxotere (Docetaxel), new antineoplastic agents]. J Pharm Belg 49:193-205 (0). Read more (PubMed: 7914532) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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